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Rheumatology International

, Volume 33, Issue 1, pp 167–172 | Cite as

Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?

  • Selda BagisEmail author
  • Mehmet Karabiber
  • İsmet As
  • Lülüfer Tamer
  • Canan Erdogan
  • Ayçe Atalay
Original Article

Abstract

The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms. Sixty premenopausal women diagnosed with fibromyalgia according to the ACR criteria and 20 healthy women whose age and weight matched the premenopausal women were evaluated. Pain intensity, pain threshold, the number of tender points, the tender point index, the fibromyalgia impact questionnaire (FIQ), the Beck depression and Beck anxiety scores and patient symptoms were evaluated in all the women. Serum and erythrocyte magnesium levels were also measured. The patients were divided into three groups. The magnesium citrate (300 mg/day) was given to the first group (n = 20), amitriptyline (10 mg/day) was given to the second group (n = 20), and magnesium citrate (300 mg/day) + amitriptyline (10 mg/day) treatment was given to the third group (n = 20). All parameters were reevaluated after the 8 weeks of treatment. The serum and erythrocyte magnesium levels were significantly lower in patients with fibromyalgia than in the controls. Also there was a negative correlation between the magnesium levels and fibromyalgia symptoms. The number of tender points, tender point index, FIQ and Beck depression scores decreased significantly with the magnesium citrate treatment. The combined amitriptyline + magnesium citrate treatment proved effective on all parameters except numbness. Low magnesium levels in the erythrocyte might be an etiologic factor on fibromyalgia symptoms. The magnesium citrate treatment was only effective tender points and the intensity of fibromyalgia. However, it was effective on all parameters when used in combination with amitriptyline.

Keywords

Fibromyalgia Magnesium Treatment 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Selda Bagis
    • 1
    • 5
    Email author
  • Mehmet Karabiber
    • 2
  • İsmet As
    • 3
  • Lülüfer Tamer
    • 4
  • Canan Erdogan
    • 3
  • Ayçe Atalay
    • 1
  1. 1.Department of Physical Medicine and RehabilitationAcıbadem University Medical SchoolIstanbulTurkey
  2. 2.Adıyaman State HospitalAdıyamanTurkey
  3. 3.Department of Physical Medicine and RehabilitationMersin University Medical SchoolMersinTurkey
  4. 4.Department of BiochemistryMersin University Medical SchoolMersinTurkey
  5. 5.Fulya Acıbadem Hastanesi, FTR, Dikilitaş Mah, Hakkıyeten cad, Yeşilçimen sokBeşiktaş-IstanbulTurkey

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