Rheumatology International

, Volume 32, Issue 4, pp 837–844 | Cite as

Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives

  • Yunpeng Zhao
  • Aijun Zhang
  • Hongxia Du
  • Shuya Guo
  • Bin Ning
  • Shangyou Yang


Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the influxation of synovia and synovial compartments with immune cells including dendritic cells (DCs). DCs that induce autoimmune tolerance are called tolerogenic DCs (tolDCs). As a promising immunotherapeutic strategy for RA, tolDCs have received increasing attention. In this review, we first introduce the significant role of tolDCs in autoimmune regulation and then describe the manipulation strategies to generate tolDCs; next, we summarize recent progress in the experimental application of tolDCs for RA therapy, and finally we discuss the perspectives of tolerogenic vaccination for the treatment for RA in clinic.


Rheumatoid arthritis Dendritic cells Tolerogenic DCs Tregs Autoimmune 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Yunpeng Zhao
    • 1
  • Aijun Zhang
    • 1
    • 2
  • Hongxia Du
    • 3
  • Shuya Guo
    • 3
  • Bin Ning
    • 1
    • 3
  • Shangyou Yang
    • 4
  1. 1.Shandong UniversityJinanChina
  2. 2.Cryomedicine LaboratoryQilu Hospital of Shandong UniversityJinanChina
  3. 3.Department of OrthopedicJinan Central Hospital Affiliated to Shandong UniversityJinanChina
  4. 4.Department of Biological SciencesWichita State UniversityWichitaUSA

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