Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with systemic lupus erythematosus and good outcome with rituximab treatment
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A patient with chronic inflammatory demyelinating polyradiculoneuropathy and systemic lupus erythematosus arising after rubella vaccination was initially treated with plasmapheresis, corticosteroids and intravenous immunoglobulins, with partial response. After shift to rituximab, most clinical symptoms improved markedly, emphasizing the possible role of this monoclonal antibody in conventional therapy-resistant cases.
KeywordsCIDP Systemic lupus erythematosous Rituximab Rubella vaccine Autoimmunity
CVGM is recipient of the Legado Peruilh Fellowship of the School of Medicine (University of Buenos Aires). Only institutional funds of either the Hospital Español or the University of Buenos Aires were used. During the course of this study, CVGM was supported by a Legado Peruilh Fellowship of the School of Medicine (University of Buenos Aires), under the direction of Dr Diez.
Conflict of interest
The authors declare that they have no conflict of interest. All authors participated in the study according to their work duties (at either the Hospital Español or the University of Buenos Aires). In addition to the affiliation to the University, Dr Diez is part-time staff of a biotechnology company, unrelated to this study. Drs Silva, García Méndez, Sanz and Giannaula participated in clinical trials sponsored by pharmaceutical companies, unrelated to the present study.
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