Rheumatology International

, Volume 32, Issue 5, pp 1121–1133 | Cite as

Evidence-based, interdisciplinary guidelines for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis

  • A. HeiligenhausEmail author
  • H. Michels
  • C. Schumacher
  • I. Kopp
  • U. Neudorf
  • T. Niehues
  • H. Baus
  • M. Becker
  • B. Bertram
  • G. Dannecker
  • C. Deuter
  • I. Foeldvari
  • M. Frosch
  • G. Ganser
  • M. Gaubitz
  • G. Gerdes
  • G. Horneff
  • A. Illhardt
  • F. Mackensen
  • K. Minden
  • U. Pleyer
  • M. Schneider
  • N. Wagner
  • M. Zierhut


Uveitis in juvenile idiopathic arthritis (JIA) is frequently associated with the development of complications and visual loss. Topical corticosteroids are the first-choice therapy, and immunosuppression is commonly used. However, treatment has not been standardized. Representatives from the German Ophthalmological Society, Society for Childhood and Adolescent Rheumatology, and the German Society for Rheumatology reached consensus on a standardized treatment strategy according to disease severity in the individual patient. The recommendations were based on a systematic literature analysis in MEDLINE and consensus expert meetings. Evidence and recommendations were graded, and an algorithm for anti-inflammatory treatment and final statements confirmed in a Delphi method. An interdisciplinary, evidence-based treatment guideline for JIA uveitis is presented.


Adolescence Children Consensus Evidence-based medicine Juvenile idiopathic arthritis Rheumatic diseases Therapy Uveitis 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • A. Heiligenhaus
    • 1
    • 2
    Email author
  • H. Michels
    • 3
  • C. Schumacher
    • 1
    • 2
  • I. Kopp
    • 4
  • U. Neudorf
    • 5
  • T. Niehues
    • 6
  • H. Baus
    • 7
  • M. Becker
    • 8
  • B. Bertram
    • 9
  • G. Dannecker
    • 10
  • C. Deuter
    • 11
  • I. Foeldvari
    • 12
  • M. Frosch
    • 13
  • G. Ganser
    • 14
  • M. Gaubitz
    • 15
  • G. Gerdes
    • 16
  • G. Horneff
    • 17
  • A. Illhardt
    • 18
  • F. Mackensen
    • 19
  • K. Minden
    • 20
  • U. Pleyer
    • 21
  • M. Schneider
    • 22
  • N. Wagner
    • 23
  • M. Zierhut
    • 11
  1. 1.Department of OphthalmologySt. Franziskus HospitalMuensterGermany
  2. 2.German Ophthalmological Society, Augenabteilung, Uveitiszentrum, St. Franziskus HospitalMünsterGermany
  3. 3.Society for Childhood and Adolescent Rheumatology, Deutsches Zentrum für Kinder- und JugendrheumatologieGarmisch PartenkirchenGermany
  4. 4.Working group of the Scientific Medical Specialty SocietiesMarburgGermany
  5. 5.Society for Childhood and Adolescent Rheumatology, Universitäts KinderklinikEssenGermany
  6. 6.Society for Childhood and Adolescent Rheumatology, HELIOS Klinikum Krefeld, Zentrum für Kinder- und JugendmedizinKrefeldGermany
  7. 7.Parents’ Association for Children with Uveitis and Their FamiliesFrankfurtGermany
  8. 8.German Ophthalmological Society, Stadtspital Triemli, AugenklinikZürichSwitzerland
  9. 9.Professional Association of Ophthalmologists, AugenarztpraxisAachenGermany
  10. 10.Society for Childhood and Adolescent Rheumatology, Olgahospital, Klinik für Kinder- und Jugendmedizin, PädiatrieStuttgartGermany
  11. 11.German Ophthalmological Society, Universitäts-AugenklinikTübingenGermany
  12. 12.Society for Childhood and Adolescent Rheumatology, Hamburger Zentrum für Kinder- und Jugendrheumatologie, Klinikum EilbeckHamburgGermany
  13. 13.Society for Childhood and Adolescent Rheumatology, Universitätskinderklinik Münster, Klinik und Poliklinik für Kinder- und JugendmedizinMünsterGermany
  14. 14.Society for Childhood and Adolescent Rheumatology, St.-Josefs-Stift, Sendenhorst, Kinder- und JugendrheumatologieSendenhorstGermany
  15. 15.German Society for Rheumatology, Akademie für Manuelle TherapieMünsterGermany
  16. 16.Parents’ Association for Children with Uveitis and Their FamiliesMünsterGermany
  17. 17.Society for Childhood and Adolescent Rheumatology, Asklepios Klinik St. Augustin, Zentrum für Kinder- und JugendmedizinSankt AugustinGermany
  18. 18.Psychologischer Dienst, St. Josef-Stift, Sendenhorst, Kinder- und JugendrheumatologieSendenhorstGermany
  19. 19.German Ophthalmological Society, Universitäts-AugenklinikHeidelbergGermany
  20. 20.Society for Childhood and Adolescent Rheumatology, Deutsches RheumaforschungszentrumBerlinGermany
  21. 21.German Ophthalmological Society, Universitätsaugenklinik, ChariteBerlinGermany
  22. 22.German Society for Rheumatology, Heinrich-Heine-Universität, Klinik, und Poliklinik für RheumatologieDüsseldorfGermany
  23. 23.Society for Childhood and Adolescent Rheumatology, Rheinisch-Westfälische Technische Hochschule, Kinder- und JugendmedizinAachenGermany

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