Rheumatology International

, Volume 32, Issue 11, pp 3691–3694 | Cite as

Low level of seroconversion after a novel influenza A/H1N1/2009 vaccination in Japanese patients with rheumatoid arthritis in the 2009 season

  • Masahiro Iwamoto
  • Sumiko Homma
  • Sachiko Onishi
  • Yasuyuki Kamata
  • Katsuya Nagatani
  • Zentaro Yamagata
  • Seiji Minota
Short Communication

Abstract

We examined change in the antibody titre against pandemic influenza A/H1N1/2009 before and after vaccination in Japanese patients with rheumatoid arthritis. This observational study was conducted with the participation of five hospitals in Japan. A total of 89 patients with rheumatoid arthritis were included in this study. The seroprotection and seroresponse rates to vaccination with the pandemic influenza A/H1N1/2009 vaccine were analysed. The seroprotection rates prior to the vaccination were 5.6% in the Japanese patients with rheumatoid arthritis. The seroprotection rates after subcutaneous vaccination were 55.1%. The seroresponse rate after subcutaneous vaccination was 50.6% in the patients with rheumatoid arthritis. Both the seroprotection and seroresponse rates obtained after the vaccination with the pandemic influenza A/H1N1/2009 vaccine were low in Japanese patients with rheumatoid arthritis. We should realise that a vaccination against this newly emerged influenza virus may protect only half of the Japanese patients with rheumatoid arthritis in a real world.

Keywords

Influenza A/H1N1/2009 Vaccination Rheumatoid arthritis 

Notes

Acknowledgments

We thank for Ms. Asumi Hirata (Tochigi Prefectural Institute of Public Health and Environmental Science) for technical advice on the HI assays.

Conflict of interest

The authors have no conflicts of interest to declare.

References

  1. 1.
    New swine-origin influenza A (H1N1) virus investigation team (2009) Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 360:2605–2615CrossRefGoogle Scholar
  2. 2.
    Echevarría-Zuno S, Mejía-Aranguré JM, Mar-Obeso A et al (2009) Infection and death from influenza A H1N1 virus in Mexico: a retrospective analysis. Lancet 374:2072–2079PubMedCrossRefGoogle Scholar
  3. 3.
    Greenberg ME, Lai MH, Hartel GF et al (2009) Response to a monovalent 2009 influenza A (H1N1) vaccine. N Engl J Med 361:2405–2413PubMedCrossRefGoogle Scholar
  4. 4.
    Zhu F-C, Wang H, Fang H-H et al (2009) A novel influenza A (H1N1) vaccine in various age groups. N Engl J Med 361:2414–2423PubMedCrossRefGoogle Scholar
  5. 5.
  6. 6.
    The Ministry of Health, Labour and Welfare in Japan. http://www.mhlw.go.jp/kinkyu/kenkou/influenza/dl/infu091111-02.pdf
  7. 7.
    Fomin I, Caspi D, Levy V et al (2006) Vaccination against influenza in rheumatoid arthritis: the effect of disease modifying drugs, including TNFα blockers. Ann Rheum Dis 65:191–194PubMedCrossRefGoogle Scholar
  8. 8.
    Kubota T, Nii T, Nanki T et al (2007) Anti-tumor necrosis factor therapy does not diminish the immune response to influenza vaccine in Japanese patients with rheumatoid arthritis. Mod Rheumatol 17:531–533PubMedCrossRefGoogle Scholar
  9. 9.
    Kapetanovic MC, Saxne T, Nisson J-Å, Geborek P (2007) Influenza vaccination as a model for testing immune modulation induced by anti-TNF and methotrexate therapy in rheumatoid arthritis patients. Rheumatology 46:608–611PubMedCrossRefGoogle Scholar
  10. 10.
    Arnett FC, Edworthy SM, Bloch DA et al (1988) The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Masahiro Iwamoto
    • 1
    • 2
    • 3
  • Sumiko Homma
    • 2
  • Sachiko Onishi
    • 1
    • 4
  • Yasuyuki Kamata
    • 1
  • Katsuya Nagatani
    • 1
    • 5
  • Zentaro Yamagata
    • 6
  • Seiji Minota
    • 1
    • 5
  1. 1.Division of Rheumatology and Clinical ImmunologyJichi Medical UniversityTochigiJapan
  2. 2.Department of MedicineJapanese Red Cross Society Koga HospitalIbarakiJapan
  3. 3.Department of MedicineShimotsuga General HospitalTochigiJapan
  4. 4.Department of MedicineUtsunomiya Social Insurance HospitalTochigiJapan
  5. 5.Department of MedicineKawakami HospitalTochigiJapan
  6. 6.Department of Health SciencesUniversity of YamanashiYamanashiJapan

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