Rheumatology International

, Volume 32, Issue 8, pp 2523–2527

Dickkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy

  • Seong-Ryul Kwon
  • Mie-Jin Lim
  • Chang-Hee Suh
  • Shin-Goo Park
  • Yeon-Sik Hong
  • Bo-Young Yoon
  • Hyoun-Ah Kim
  • Hyo-Jin Choi
  • Won Park
Original Article

Abstract

(1) To compare the serum levels of Dickkopf-1 (DKK-1) and bone biomarkers in patients with ankylosing spondylitis (AS) and healthy controls. (2) To examine the effects of anti-tumor necrosis factor-α (TNF-α) therapy for 3 months on bone biomarkers in patients with AS. We measured the levels of DKK-1, osteocalcin, osteoprotegerin, and C-terminal telopeptide of type I collagen (CTX-1) in patients with AS and in healthy controls at baseline and 3 months after initiating anti-TNF-α therapy in AS patients. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were also measured before and after anti-TNF-α therapy in AS patients. Serum levels of DKK-1 were significantly lower in the AS patients than in the controls (P < 0.0001). Osteocalcin and osteoprotegerin levels were significantly higher in the AS patients than in the controls (P < 0.0001). Serum levels of DKK-1 were not changed after the 3-month anti-TNF-α therapy. Osteocalcin level increased (P < 0.0001), osteoprotegerin level and BASDAI scores decreased (P = 0.025 and P < 0.0001, respectively) significantly after the 3-months anti-TNF-α therapy. Serum DKK-1 level was lower in patients with AS than in healthy controls and did not change after 3 months of anti-TNF-α therapy in the AS patients despite the marked improvement in BASDAI scores. These findings suggest the low serum DKK-1 level is related to the pathogenesis of new bone formation in AS, which is resistant to TNF-α blocking therapy.

Keywords

Dickkopf-1 Ankylosing spondylitis TNF blocker Osteocalcin Osteoprotegerin CTX-1 BASDAI 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Seong-Ryul Kwon
    • 1
  • Mie-Jin Lim
    • 1
  • Chang-Hee Suh
    • 2
  • Shin-Goo Park
    • 3
  • Yeon-Sik Hong
    • 4
  • Bo-Young Yoon
    • 5
  • Hyoun-Ah Kim
    • 2
  • Hyo-Jin Choi
    • 6
  • Won Park
    • 1
  1. 1.Rheumatism CenterInha University HospitalIncheonRepublic of Korea
  2. 2.Department of RheumatologyAjou University School of MedicineSuwonRepublic of Korea
  3. 3.Department of Occupation and Environmental MedicineInha University HospitalIncheonRepublic of Korea
  4. 4.Department of RheumatologySt. Mary’s HospitalIncheonRepublic of Korea
  5. 5.Department of RheumatologyInje University Ilsan Paik HospitalGoyangRepublic of Korea
  6. 6.Department of RheumatologyGachon School of Medicine, Gachon University of Medicine and ScienceIncheonRepublic of Korea

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