Rheumatology International

, Volume 32, Issue 7, pp 2083–2092 | Cite as

Association of TNF-α promoter-308 A/G polymorphism with susceptibility to systemic lupus erythematosus: a meta-analysis

  • Hai-Feng Pan
  • Rui-Xue Leng
  • Chao Wang
  • Wei-Zi Qin
  • Li-Li Chen
  • Zhen-Qiu Zha
  • Jin-Hui Tao
  • Dong-Qing Ye
Original Article

Abstract

Published data on the association between tumor necrosis factor-alpha (TNF-α) promoter-308 A/G polymorphism and systemic lupus erythematosus (SLE) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 28 studies including 2,992 cases and 4,326 controls (5,924 cases and 8,484 controls in A versus G comparison) were involved in this meta-analysis. Meta-analysis was performed for genotypes A/A (recessive effect), A/A+A/G (dominant effect), and A allele in fixed or random effects models. In addition, we also performed a “model-free” analysis by considering the G/G genotype as the reference and estimated the OR for the A/A versus G/G and A/G versus G/G genotype. Overall, an association of TNF-α promoter-308 A/G polymorphism with SLE was found (A versus G: OR = 1.686, 95% CI = 1.400–2.032, P < 0.001; A/A versus A/G+G/G: OR = 3.043, 95% CI = 2.185–4.238, P < 0.001; A/A+A/G versus G/G: OR = 1.822, 95% CI = 1.379–2.407, P < 0.001; A/A versus G/G: OR = 3.686, 95% CI = 2.628–5.172, P < 0.001; A/G versus G/G: OR = 1.691, 95% CI = 1.291–2.215, P < 0.001). However, stratification by ethnicity indicated that the risk A allele was not associated with SLE in Asian (A versus G: OR = 1.207, 95% CI = 0.856–1.702, P = 0.283) and African population (A versus G: OR = 1.225, 95% CI = 0.597–2.516, P = 0.580). In summary, this meta-analysis indicated that TNF-α promoter-308-A/G polymorphism is associated with susceptibility to SLE.

Keywords

Meta-analysis Susceptibility Systemic lupus erythematosus TNF-α 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Hai-Feng Pan
    • 1
  • Rui-Xue Leng
    • 1
  • Chao Wang
    • 1
  • Wei-Zi Qin
    • 1
  • Li-Li Chen
    • 1
  • Zhen-Qiu Zha
    • 1
  • Jin-Hui Tao
    • 1
    • 2
  • Dong-Qing Ye
    • 1
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Department of RheumatologyAnhui Provincial HospitalHefeiPeople’s Republic of China

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