Rheumatology International

, Volume 32, Issue 5, pp 1437–1441 | Cite as

Possible anti-metastatic effect of Iloprost in a patient with systemic sclerosis with lung cancer: a case study

  • Yavuz PehlivanEmail author
  • Ibrahim Halil Turkbeyler
  • Ozan Balakan
  • Alper Sevinc
  • Mustafa Yilmaz
  • Kemal Bakir
  • Ahmet Mesut Onat
Short Communication


Systemic Sclerosis (SSc) is a chronic disease of unknown etiology which affects the vascular system and connective tissue. A wide series of studies showed an increased prevalence of cancer in patients with SSc than the normal population. Prostacyclin (PGI2) is an endogenously produced element that is basically synthesized by arachiodonic acid through prostacyclin synthesis in vascular system endothelial cells. Iloprost is a stable analogue of PGI2 which is used in the treatment of pulmonary arterial hypertension (PAH). In a limited number of animal models, the anti-metastatic activity of PGI2 is observed. Herein, we report iloprost treatment of a 60-year-old-woman with SSc, who lately developed PAH as a complication of her disease and lung adenocarcinoma as a co-incidence simultaneously. These two mortal complications were both treated successfully with inhaled iloprost until her death due to gastrointestinal complications of SSc.


Lung adenocarcinoma Prostacyclin analogue Inhaled iloprost Anti-metastatic activity Pulmonary arterial hypertension Systemic Sclerosis 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Yavuz Pehlivan
    • 1
    Email author
  • Ibrahim Halil Turkbeyler
    • 2
  • Ozan Balakan
    • 3
  • Alper Sevinc
    • 3
  • Mustafa Yilmaz
    • 4
  • Kemal Bakir
    • 5
  • Ahmet Mesut Onat
    • 1
  1. 1.School of Medicine, Departments of Rheumatologyn, Sahinbey Medical CenterGaziantep UniversityGaziantepTurkey
  2. 2.School of Medicine, Departments of Internal Medicine, Sahinbey Medical CenterGaziantep UniversityGaziantepTurkey
  3. 3.School of Medicine, Departments of Medical Oncology, Gaziantep Oncology HospitalGaziantep UniversityGaziantepTurkey
  4. 4.School of Medicine, Departments of Nukleer Medicine, Gaziantep Oncology HospitalGaziantep UniversityGaziantepTurkey
  5. 5.School of Medicine, Departments of Pathology, Sahinbey Medical CenterGaziantep UniversityGaziantepTurkey

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