Rheumatology International

, Volume 31, Issue 12, pp 1669–1671

Should we really compare absolute risk reduction in different trials on osteoporosis: comment on the article by Ringe JD and Doherty JG

Letter to the Editor


  1. 1.
    Ringe JD, Doherty JG (2009) Absolute risk reduction in osteoporosis: assessing treatment efficacy by number needed to treat. Rheumatology International, published online 25 Dec 2009, doi:10.1007/s00296-009-1311-y
  2. 2.
    Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, Cannata J, Dalogh A, Lemmel E, Nielsen S, Rizzoli R, Genant HK, Reginster J (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350:459–468PubMedCrossRefGoogle Scholar
  3. 3.
    Chesnut CH, Skag A, Christiansen C, Recker R, Stakkestad JA, Hoiseth A, Felsenberg D, Huss H, Gibride J, Schimmer RC, Delmas PD (2004) Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res 19:1241–1249CrossRefGoogle Scholar
  4. 4.
    Campbel MJ, Machin D (2003) Medical statistics a commonsense approach, pp 62–63Google Scholar
  5. 5.
    Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385–397PubMedCrossRefGoogle Scholar
  6. 6.
    Reginster JY, Seeman E, Vernejoul MC, Adami S, Compston J, Phenekos C, Devogelaer JP, Curiel MD, Sawicki A, Goemaere S, Sorensen OH, Felsenberg D, Meunier PJ (2005) Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90:2816–2822PubMedCrossRefGoogle Scholar
  7. 7.
    Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, Cosman F, Lakatos P, Leung PC et al (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356:1809–1822PubMedCrossRefGoogle Scholar
  8. 8.
    O’Donnel S, Cranney A, Wells GA, Adachi J, Reginster JY (2008) Strontium ranelate for preventing and treating osteoporosis. The Cochrane Library, Issue 4Google Scholar
  9. 9.
    Wilkes MM, Navickis RJ, Chan WW, Lewiecki EM (2010) Bisphosphonates and osteoporotic fractures: a cross-design synthesis of results among compliant/persistent postmenopausal women in clinical practice versus randomized controlled trials. J Osteoporos Int 21:679–688CrossRefGoogle Scholar
  10. 10.
    O’Donnell S, Moher D, Kelli Thomas K, Hanley DA, Cranney A (2008) Systematic review of the benefits and harms of calcitriol and alfacalcidol for fractures and falls. J Bone Miner Metab 26:531–542PubMedCrossRefGoogle Scholar
  11. 11.
    Cummings SR, Martin JS, McClung MR, Siris ES, Eastell R, Reid IR, Pierre Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C (2009) For the Freedom trial: denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361:756–765PubMedCrossRefGoogle Scholar
  12. 12.
    Recker RR, Marin F, Ish-Shalom S, Moricke R, Hawkins F, Kapetanos G, de la Pena MP, Kekow J, Farrerons J, Sanz B, Oertel H, Stepan J (2009) Comparative effects of teriparatide and strontium ranelate on bone biopsies and biochemical markers of bone turnover in postmenopausal women with osteoporosis. J Bone Miner Res 24:1358–1368PubMedCrossRefGoogle Scholar
  13. 13.
    Blake CB, Compston JE, Fogelman I (2009) Could strontium ranelate have a synergistic role in the treatment of osteoporosis? J Bone Miner Res 24. Published online on 15 June. doi:10.1359/JBMR.090601
  14. 14.
    Li C, Paris O, Siegel S, Roschger P, Paschali EP, Klaushofer, Fratzl KP (2009) Strontium is incorporated into mineral crystals only in newly formed bone during strontium ranelate treatment. JBMR [epub ached of printing]Google Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.The National Research Center for EndocrinologyMoscowRussia

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