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Rheumatology International

, Volume 32, Issue 1, pp 193–198 | Cite as

Serum uric acid predicts changes in reports of non-gouty chronic pain: a prospective study among women with inflammatory and non-inflammatory pain

  • H. Ingemar AnderssonEmail author
  • Ido Leden
Original Article

Abstract

Widespread pain has earlier been associated with an increase in serum urate (SU). The aim of this study was to longitudinally study the relation between changes in pain reporting and the level of SU among women with chronic pain. Consecutive female patients (n = 124; aged 20–70 years), at rheumatology and rehabilitation practices, with chronic musculoskeletal pain of different origins were followed for 1 year with repeated blood samples and questionnaires. Complete data were obtained from 107 individuals. Factors that predicted an increase in pain extension during 12 months were studied in a logistic regression model. Changes in SU showed a significant correlation (r = 0.36) with changes in the number of reported pain locations. An initially high SU level (OR = 4.46), frequent use of alcohol (OR = 1.32) and a high number of pain locations (OR = 1.24) independently predicted an increase in pain extension during 12 months, whereas the use of steroids (OR = 0.21) in patients with inflammatory disorders resulted in a decreased number of reported pain locations. A relative increase in SU in combination with report of a high number of pain locations turned out to be a risk factor of increased pain extension in a cohort of women with chronic non-gouty pain followed during 1 year. The importance of SU in relation to chronic pain and its prognosis needs to be validated in larger studies.

Keywords

Uric acid Non-gouty pain Pain extension Widespread pain 

References

  1. 1.
    Bergman S, Herrstrom P, Jacobsson LTH, Petersson IF (2002) Chronic widespread pain: a three year follow-up of pain distribution and risk factors. J Rheumatol 29(4):818–825PubMedGoogle Scholar
  2. 2.
    Papageorgiou AC, Silman AJ, Macfarlane GJ (2002) Chronic widespread pain in the population: a seven year follow up study. Ann Rheum Dis 61(12):1071–1074PubMedGoogle Scholar
  3. 3.
    Andersson HI, Ejlertsson G, Leden I, Rosenberg C (1996) Characteristics of subjects with chronic pain, in relation to local and widespread pain report. A prospective study of symptoms, clinical findings and blood tests in subgroups of a geographically defined population. Scand J Rheumatol 25:146–154PubMedGoogle Scholar
  4. 4.
    Kadam UT, Thomas E, Croft PR (2005) Is chronic widespread pain a predictor of all-cause morbidity? A 3 year prospective population based study in family practice. J Rheumatol 32(7):1341–1348PubMedGoogle Scholar
  5. 5.
    Kamaleri Y, Natvig B, Ihlebaek CM, Benth JS, Bruusgaard D (2008) Number of pain sites is associated with demographic, lifestyle, and health-related factors in the general population. Eur J Pain 12(6):742–748PubMedGoogle Scholar
  6. 6.
    Andersson HI (2004) The course of non-malignant chronic pain: a 12-year follow-up of a cohort from the general population. Eur J Pain 8(1):47–53PubMedGoogle Scholar
  7. 7.
    Macfarlane GJ, McBeth J, Silman AJ (2001) Widespread body pain and mortality: prospective population based study. BMJ 323(7314):662–664PubMedGoogle Scholar
  8. 8.
    McBeth J, Symmons DP, Silman AJ, Allison T, Webb R, Brammah T, Macfarlane GJ (2009) Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular–related mortality. Rheumatology (Oxford) 48:74–77Google Scholar
  9. 9.
    Andersson HI (2009) Increased mortality among individuals with chronic widespread pain relates to lifestyle factors: a prospective population-based study. Disabil Rehabil 21:1–8Google Scholar
  10. 10.
    Mäntyselkä P, Miettola J, Niskanen L, Kumpusalo E (2008) Glucose regulation and chronic pain at multiple sites. Rheumatology (Oxford) 47(8):1235–1238Google Scholar
  11. 11.
    Aarflot T, Laerum E, Bruusgaard D (1992) Uric acid and chronic musculoskeletal complaints. Scand J Rheumatol 21:277–282PubMedGoogle Scholar
  12. 12.
    Aarflot T, Bruusgaard D (1994) Chronic musculoskeletal complaints and subgroups with special reference to uric acid. Scand J Rheumatol 23:25–29PubMedGoogle Scholar
  13. 13.
    Onat A, Uyarel H, Hergenç G, Karabulut A, Albayrak S, Sari I, Yazici M, Keleş I (2006) Serum uric acid is a determinant of metabolic syndrome in a population-based study. Am J Hypertens 19(10):1055–1062PubMedGoogle Scholar
  14. 14.
    Waring WS, Convery AA, Mishra V, Shenkin A, Webb DJ, Maxwell SR (2003) Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci 105(4):425–430PubMedGoogle Scholar
  15. 15.
    Niskanen LK, Laaksonen DE, Nyyssonen K, Alfthan G, Lakka HM, Lakka TA, Salonen JT (2004) Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med 164(14):1546–1551PubMedGoogle Scholar
  16. 16.
    Chen JH, Chuang SY, Chen HJ, Yeh WT, Pan WH (2009) Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum 61(2):225–232PubMedGoogle Scholar
  17. 17.
    Andersson HI, Leden I (2006) Increased serum uric acid—a marker of non-gouty widespread pain? A study of female patients with inflammatory and non-inflammatory pain. Scand J Rheumatol 35(4):261–267PubMedGoogle Scholar
  18. 18.
    Edwards RR (2005) Individual differences in endogenous pain modulation as a risk factor for chronic pain. Neurology 65(3):437–443PubMedGoogle Scholar
  19. 19.
    Bruehl S, McCubbin JA, Harden RN (1999) Theoretical review: altered pain regulatory systems in chronic pain. Neurosci Biobehav Rev 23(6):877–890PubMedGoogle Scholar
  20. 20.
    Becker BF (1993) Towards the physiological function of uric acid. Free Radic Biol Med 14:615–631PubMedGoogle Scholar
  21. 21.
    Schell E, Theorell T, Hasson D, Arnetz B, Saraste H (2008) Stress biomarkers′ associations to pain in the neck, shoulder and back in healthy media workers: 12 month prospective follow-up. Eur Spine J 17:393–405PubMedGoogle Scholar
  22. 22.
    Choe JY, Park SH, Kim JY, Shin IH, Kim SK (2008) Change in serum uric acid between baseline and 1-year follow-up and its associated factors in male subjects. Clin Rheumatol 27(4):483–489PubMedGoogle Scholar
  23. 23.
    Kalamaleri Y, Natvig B, Ihlebaek CM, Saltyte Benth J, Bruusgaard D (2009) Change in the number of musculoskeletal pain sites: a 14-year prospective study. Pain 141:25–30Google Scholar
  24. 24.
    Ozgocmen S, Ozyurt H, Sogut S, Akyol O (2006) Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide. Rheumatol Int 26:585–597PubMedGoogle Scholar
  25. 25.
    Robinson KL, McBeth J, MacFarlane GJ (2004) Psychological distress and premature mortality in the general population: a prospective study. Ann Epidemiol 14(7):467–472PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.School of Health and SocietyKristianstad UniversityKristianstadSweden
  2. 2.Division of Rheumatology, Department of MedicineCentral HospitalKristianstadSweden

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