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Rheumatology International

, Volume 31, Issue 6, pp 819–822 | Cite as

Down-regulated expression of IKZF1 mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

  • Wenlong Hu
  • Liangdan Sun
  • Jinping Gao
  • Yun Li
  • Peiguang Wang
  • Yilin Cheng
  • Tingmeng Pan
  • Jianwen Han
  • Yangsheng Liu
  • Wensheng Lu
  • Xianbo Zuo
  • Yujun Sheng
  • Sha Yao
  • Caifeng He
  • Zeying Yu
  • Xianyong Yin
  • Yong Cui
  • Sen Yang
  • Xuejun Zhang
Short Communication

Abstract

Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with complex genetic inheritance. IKZF1 was established as a new susceptibility gene for SLE in a recent genome-wide association study (GWAS) in Chinese Han population. In order to examine whether expression levels of IKZF1 contribute to the pathogenesis of SLE, we estimated IKZF1 mRNA expression levels in peripheral blood mononuclear cells (PBMCs) via fluorescent quantitative reverse transcription polymerase chain reaction (RT-PCR) in 60 patients with SLE and 60 controls. We also explored whether the IKZF1 mRNA expression levels are associated with the variant of the SNP rs4917014 and the SLE Disease Activity Index (SLEDAI). The expression levels of IKZF1 mRNA in patients with SLE were significantly decreased compared with those in healthy controls (P < 0.001). No significant differences were found between IKZF1 mRNA expression levels and SLEDAI scores, SNP rs4917014. Our results suggest that decreased expression of IKZF1 mRNA may be correlated with the pathogenesis of SLE.

Keywords

IKZF1 Peripheral blood mononuclear cells Real-time reverse transcription–polymerase chain reaction Systemic lupus erythematosus 

Notes

Acknowledgments

This work was supported by a grant from the General Program of National Natural Science Foundation of China (30972727) and the Foundation of the Excellent Young Scientist of Anhui Province (10040606Y10), We are most grateful to all the members who have so willingly participated in this study, which made this study possible.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Wenlong Hu
    • 1
    • 2
  • Liangdan Sun
    • 1
    • 2
  • Jinping Gao
    • 1
    • 2
  • Yun Li
    • 1
    • 2
  • Peiguang Wang
    • 1
    • 2
  • Yilin Cheng
    • 2
  • Tingmeng Pan
    • 1
    • 2
  • Jianwen Han
    • 1
    • 2
  • Yangsheng Liu
    • 1
    • 2
  • Wensheng Lu
    • 1
    • 2
  • Xianbo Zuo
    • 2
  • Yujun Sheng
    • 1
    • 2
  • Sha Yao
    • 1
    • 2
  • Caifeng He
    • 1
    • 2
  • Zeying Yu
    • 1
    • 2
  • Xianyong Yin
    • 2
  • Yong Cui
    • 1
    • 2
  • Sen Yang
    • 1
    • 2
  • Xuejun Zhang
    • 1
    • 2
  1. 1.Institute of Dermatology and Department of DermatologyThe First Affiliated Hospital, Anhui Medical UniversityHefeiChina
  2. 2.The Key Lab of DermatologyMinistry of Education of the People’s Republic of ChinaHefeiChina

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