Rheumatology International

, Volume 31, Issue 3, pp 421–423 | Cite as

SNP–SNP interactions within APOE gene influence plasma lipids in postmenopausal osteoporosis

  • Monica Singh
  • Puneetpal Singh
  • Pawan Kumar Juneja
  • Surinder Singh
  • Taranpal Kaur
Letter to the Editor

Dear Sirs,

Biological revelations have gradually started clearing the complex relationships of bones with lipids. Studies have shown that lipid profiles are related to bone mass, bone fragility and fracture risk [1, 2]. It has been observed that oxidized lipids inhibit mineralization of bone, induce osteoblastic differentiation in vascular cells, and hyperlipidemia reduces bone density in mice [3].

To understand the genetic link between lipids and osteoporosis risk, apolipoprotein E gene (APOE) is a potential candidate because of its vital contribution to both lipid and vitamin K metabolism. APOE is located on the chromosome 19q13.2 and has three codominant alleles i.e. APOE2, APOE3 and APOE4. It serves as a ligand for receptor-mediated uptake of lipoprotein particles, which are the main carriers of vitamin K, and availability of vitamin K is an essential step for the carboxylation of glutamic acid residues of osteocalcin, an important bone protein. A study has shown that decrease in...


Bone Mineral Density Osteoporosis Hormone Replacement Therapy Premature Ovarian Failure Osteoporotic Woman 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The project was funded by the DST, New Delhi under the grant (SR/WOS-A/LS-225/2007), which is highly acknowledged.

Conflict of interest statement

All the authors have no conflict of interest.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Monica Singh
    • 1
  • Puneetpal Singh
    • 1
  • Pawan Kumar Juneja
    • 2
  • Surinder Singh
    • 2
  • Taranpal Kaur
    • 3
  1. 1.Molecular Genetics Laboratory, Department of Human BiologyPunjabi UniversityPatialaIndia
  2. 2.Aggarwal Orthopedic HospitalLudhianaIndia
  3. 3.Amrit Poly ClinicFerozepurIndia

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