Rheumatology International

, Volume 31, Issue 3, pp 421–423 | Cite as

SNP–SNP interactions within APOE gene influence plasma lipids in postmenopausal osteoporosis

  • Monica Singh
  • Puneetpal Singh
  • Pawan Kumar Juneja
  • Surinder Singh
  • Taranpal Kaur
Letter to the Editor


  1. 1.
    Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q, Chihara K (2002) Plasma lipids and osteoporosis in postmenopausal women. Endocr J 49:211–217CrossRefPubMedGoogle Scholar
  2. 2.
    Sivas F, Alemdaroğlu E, Elverici E, Kuluğ T, Ozoran K (2009) Serum lipid profile: its relationship with osteoporotic vertebrae fractures and bone mineral density in Turkish postmenopausal women. Rheumatol Int 29:885–890CrossRefPubMedGoogle Scholar
  3. 3.
    Parhami F (2003) Possible role of oxidized lipids in osteoporosis: could hyperlipidemia be a risk factor? Prostaglandins Leukot Essent Fatty Acids 68:373–378CrossRefPubMedGoogle Scholar
  4. 4.
    Kohlmeier M, Saupe J, Schaefer K, Asmus G (1998) Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype. Calcif Tissue Int 62:278–281CrossRefPubMedGoogle Scholar
  5. 5.
    Hak AE, Witteman JC, Hugens W, Keyzer JJ, Pop VJ, Uitterlinden AG, Pols HA (2004) The increase in cholesterol with menopause is associated with the apolipoprotein E genotype. A population-based longitudinal study. Atherosclerosis 175:169–176CrossRefPubMedGoogle Scholar
  6. 6.
    Heikkinen AM, Niskanen L, Ryynänen M, Komulainen MH, Tuppurainen MT, Parviainen M, Saarikoski S (1999) Is the response of serum lipids and lipoproteins to postmenopausal hormone replacement therapy modified by ApoE genotype? Arterioscler Thromb Vasc Biol 19:402–407PubMedGoogle Scholar
  7. 7.
    Long JR, Zhao LJ, Liu PY et al (2004) Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. BMC Genetics 5:11–17CrossRefPubMedGoogle Scholar
  8. 8.
    Ma L, Runesha HB, Dvorkin D, Garbe JR, Da Y (2008) Parallel and serial computing tools for testing single-locus and epistatic SNP effects of quantitative traits in genome-wide association studies. BMC Bioinformatics 9:315CrossRefPubMedGoogle Scholar
  9. 9.
    He LN, Recker RR, Deng HW, Dvornyk V (2009) A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females. Maturitas 62:37–41CrossRefPubMedGoogle Scholar
  10. 10.
    Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G, Puca AA (2008) Lack of replication of genetic associations with human longevity. Biogerontology 9:85–92CrossRefPubMedGoogle Scholar
  11. 11.
    Martin ER, Lai EH, Gilbert JR et al (2000) SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am J Hum Genet 67:383–394CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Monica Singh
    • 1
  • Puneetpal Singh
    • 1
  • Pawan Kumar Juneja
    • 2
  • Surinder Singh
    • 2
  • Taranpal Kaur
    • 3
  1. 1.Molecular Genetics Laboratory, Department of Human BiologyPunjabi UniversityPatialaIndia
  2. 2.Aggarwal Orthopedic HospitalLudhianaIndia
  3. 3.Amrit Poly ClinicFerozepurIndia

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