Rheumatology International

, Volume 30, Issue 11, pp 1411–1416 | Cite as

Atherosclerosis and endothelial dysfunction in patients with ankylosing spondylitis

Review

Abstract

Ankylosing spondylitis (AS) is a systemic inflammatory rheumatic disease characterized primarily by axial joint involvement, sacroiliitis and various extra-articular manifestations. High cardiovascular mortality in AS has led many researchers to investigate possible risk factors involved with cardiovascular disease in these patients. This review summarizes published data concerning endothelial dysfunction and atherosclerosis in patients with AS. The author discusses current limitations and problems related to a better assessment of these two possible changes in AS.

Keywords

Spondylarthropathies Ankylosing Spondylitis Inflammation Biomarkers Cardiovascular disease Atherosclerosis Endothelial activation Endothelial dysfunction Arterial stiffness 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Head of Spondylarthropathies ServiceFederal University of ParanáRebouças-CuritibaBrazil
  2. 2.Graduate Program in Health SciencesPontificia Universidade Catolica do ParanaCuritibaBrazil

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