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Rheumatology International

, Volume 31, Issue 4, pp 485–491 | Cite as

Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis

  • Han-Gyul Yoo
  • Sang-Il Lee
  • Han-Jung Chae
  • Seoung Ju Park
  • Yong Chul Lee
  • Wan-Hee Yoo
Original Article

Abstract

The study was performed to confirm the high prevalence of metabolic syndrome in gouty patients and to define the relationship between insulin resistance and gouty arthritis. We recruited 83 patients with gouty arthritis and checked clinical factors according to the diagnostic criteria of metabolic syndrome from the ATP III guidelines and WHO Asia-Pacific obesity criteria recommendations. We also assessed the clinical characteristics of subjects and homeostasis model assessment of insulin resistance (HOMA-IR) and compared with previous study groups as controls. The prevalence of metabolic syndrome in patients with gout was 30.1% according to ATP III criteria and 50.6% with WHO Asia-Pacific adjustment and is significantly higher than the previous control study groups (ATP III: 5.2, 10.6%, WHO Asia-Pacific adjustment: 9.8, 13.9%). The mean value of HOMA-IR in patients with gout was 2.63 ± 1.36 and is significantly higher than control study (1.91 ± 1.01, P < 0.05). There were significant correlations between 24-h urinary uric acid excretion and waist circumference (r 2 = 0.225, P = 0.049), fasting insulin (r 2 = 0.241, P = 0.035), and insulin resistance (HOMA-IR) (r 2 = 0.271, P = 0.017). There were significant correlations between insulin resistance and waist circumference (r 2 = 0.341, P < 0.01), BMI (r 2 = 0.390, P < 0.01). The value of HOMA-IR (insulin resistance) and the prevalence of metabolic syndrome in patients with gout are significantly higher than normal healthy control groups. The hyperuricemia in gout might be caused by the increased adiposity associated with insulin resistance.

Keywords

Gout Insulin resistance Metabolic syndrome 

Notes

Acknowledgments

This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A084144).

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Han-Gyul Yoo
    • 1
  • Sang-Il Lee
    • 2
  • Han-Jung Chae
    • 3
    • 5
  • Seoung Ju Park
    • 4
    • 5
  • Yong Chul Lee
    • 4
    • 5
  • Wan-Hee Yoo
    • 4
    • 5
  1. 1.Department of Pharmacy PracticeUniversity of Rhode IslandKingstonUSA
  2. 2.Department of Internal MedicineGyeongsang National University School of MedicineJinjuSouth Korea
  3. 3.Department of PharmacologyChonbuk National University Medical SchoolJeonjuSouth Korea
  4. 4.Department of Internal MedicineChonbuk National University Medical School and Research Institute of Clinical MedicineJeonjuSouth Korea
  5. 5.Research Center for Pulmonary DisordersChonbuk National University Medical School and Research Institute of Clinical MedicineJeonjuSouth Korea

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