Anti-TNF therapies: a comprehensive analysis of adverse effects associated with immunosuppression
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Knowledge and understanding about the immunosuppressive properties of anti-TNF therapies and the adverse effects these causes have advanced over the last 10 years since the first of these drugs was approved. These drugs work by inhibiting tumour necrosis factor (TNF) in the body, which plays an essential role in the immune response to invading pathogens. Anti-TNF drugs have therapeutic value because high levels of TNF are thought to be part of the pathophysiology of many chronic inflammatory disorders such as rheumatoid arthritis and Crohn’s disease. Anti-TNF drugs are usually well-tolerated, however, there have been reports of many potentially serious adverse effects. This article will comprehensively analyse these adverse effects; the incidence, symptoms and mechanisms will be discussed. In addition, the contraindications of this class of drugs will be explored and the detection and prevention methods that should be put in place by health care professionals who treat patients on these drugs will be described.
KeywordsAnti-TNF Biologics Immunosuppresion Adverse effects Rheumatology
Conflict of interest statement
There are no conflicts of interest for this author.
- 3.Olsen NJ, Stein CM (2004) New drugs for rheumatoid arthritis. N Engl J Med 350(21):2167–2179, 2226Google Scholar
- 9.Antoni C, Braun J (2002) Side effects of anti-TNF therapy: current knowledge. Clinl Exp Rheumatol 20(6 Suppl 28):S152–S157Google Scholar
- 10.Weinberg JM, Buchholz R (2006) TNF-alpha inhibitors, 1st edn. Birkh©Þuser Verlag, BaselGoogle Scholar
- 11.Stone JH (2008) Tumor necrosis factor-alpha inhibitors: risk of bacterial, viral, and fungal infections. http://www.uptodate.com/online/content/topic.do?topicKey=immuninf/8844. Accessed Oct 2008
- 13.Stone JH (2008) Tumor necrosis factor-alpha inhibitors: risk of malignancy. http://www.uptodate.com/online/content/topic.do?topicKey=tx_rheum/14969. Accessed Oct 2008
- 14.Robinson WH, Genovese MC, Moreland LW (2001) Demyelinating and neurologic events reported in association with tumor necrosis factor α antagonism: by what mechanisms could tumor necrosis factor an antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis? Arthritis Rheum 44(9):1977–1983CrossRefPubMedGoogle Scholar
- 15.Stone JH (2008) Tumor necrosis factor-alpha inhibitors: an overview of adverse effects. http://www.uptodate.com/online/content/topic.do?topicKey=tx_rheum/12761&source=HISTORY. Accessed Oct 2008
- 19.Stone JH (2008) Tumor necrosis factor-alpha inhibitors: induction of antibodies, autoantibodies, and autoimmune diseases. http://www.uptodate.com/online/content/topic.do?topicKey=tx_rheum/14677. Accessed Oct 2008