Rheumatology International

, Volume 30, Issue 5, pp 587–590

The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China

  • Xiang Liu
  • Li-Hua Hu
  • Yi-Rong Li
  • Feng-Hua Chen
  • Yong Ning
  • Qun-Feng Yao
Original Article

Abstract

The aim of this study was to investigate the association of the B27 subtypes with ankylosing spondylitis (AS) in the Wuhan population of China. We selected 317 HLA-B27-positive individuals (145 controls and 172 patients with ankylosing spondylitis). The B27 subtypes were characterized using a PCR-SSP method. Six B27 subtypes were determined: B*2702, 03, 04, 05, 06 and B*13. HLA-B*2704 and HLA-B*2705 were the two high frequency genotypes in controls and patients. Compared with the controls, the AS patients had high frequency of B*2704 (patients 69.2% vs. controls 53.8%) and low frequency of B*2705 (patients 23.8% vs. controls 33.1%). B*2703 was detected in 10 (5.8%) patients and in 13 (8.9%) controls. B*2702, 06 and B*2713 were relatively rare. Our results show that the allele conferring risk to AS in the Wuhan population of China was B*2704 and B*2705. B*2704 is strongly associated with AS.

Keywords

Human leukocyte antigen Wuhan HLA-B27 Subtypes Ankylosing spondylitis 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Xiang Liu
    • 1
    • 2
  • Li-Hua Hu
    • 1
  • Yi-Rong Li
    • 1
  • Feng-Hua Chen
    • 1
  • Yong Ning
    • 2
  • Qun-Feng Yao
    • 2
  1. 1.Clinical Laboratory Medicine Department, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Medical Laboratory and TechnologyHubei College of Traditional Chinese MedicineWuhanChina

Personalised recommendations