Diffuse proliferative glomerulonephritis associated with dermatomyositis with nephrotic syndrome
- First Online:
We described a 44-year-old man developing dermatomyositis (DM) and nephrotic syndrome (NS). Renal biopsy revealed diffuse proliferative glomerulonephritis (DPGN) with depositions of immunoglobulin and complements. A combination therapy of steroid and cyclophosphamide (CTX) was found very effective for the patient. Chronic glomerulonephritis is rare in DM. In our review of related literature, membranous glomerulonephritis (MN) is the main type of glomerular lesion, another type is mesangial proliferative glomerulonephritis (mesPGN). Here we reported a case of DM associated with DPGN developing NS, which was not found in existing literature. Although glomerulonephritis is uncommon in patients with DM, renal pathology is not as simplex as previously thought, and treatment with steroid or/and cytotoxic drugs is favorable for prognosis.
KeywordsDermatomyositis Glomerulonephritis Nephrotic syndrome Treatment
- 1.Bohan A, Peter JB (1975) Polymyositis and dermatomyositis. N Engl J Med 292:344–347, 403–407Google Scholar
- 11.Hosoda T, Toshida S, Mimori T, Toguchi T, Inada S, Tomii M, Yamagata H, Akizuki M, Abe T (1981) Polymyositis associated with interstitial pulmonary fibrosis and glomerulonephritis. A report of two autopsy cases. Ryumachi 21(Suppl):S183–S188Google Scholar
- 14.Yasunobu T, Hiroko K, Kojiro S, Kimito K, Akihiro Y, Hiroshi U, Jan S, Shoji T, Yashikata M, Kazuhiko Y (2007) Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes. Clin Rheumatol 26:792–796. doi:10.1007/s10067-006-0200-y CrossRefGoogle Scholar