Rheumatology International

, Volume 30, Issue 6, pp 821–825 | Cite as

Diffuse proliferative glomerulonephritis associated with dermatomyositis with nephrotic syndrome

  • Qibing Xie
  • Yi Liu
  • Gang Liu
  • Nanping Yang
  • Geng Yin
Case Report


We described a 44-year-old man developing dermatomyositis (DM) and nephrotic syndrome (NS). Renal biopsy revealed diffuse proliferative glomerulonephritis (DPGN) with depositions of immunoglobulin and complements. A combination therapy of steroid and cyclophosphamide (CTX) was found very effective for the patient. Chronic glomerulonephritis is rare in DM. In our review of related literature, membranous glomerulonephritis (MN) is the main type of glomerular lesion, another type is mesangial proliferative glomerulonephritis (mesPGN). Here we reported a case of DM associated with DPGN developing NS, which was not found in existing literature. Although glomerulonephritis is uncommon in patients with DM, renal pathology is not as simplex as previously thought, and treatment with steroid or/and cytotoxic drugs is favorable for prognosis.


Dermatomyositis Glomerulonephritis Nephrotic syndrome Treatment 



We wish to thank Chen YT, Lin H, Wang ZM (Department of Rheumatology, Sichuan University, China) for advice in preparing figures and manuscript.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Qibing Xie
    • 1
  • Yi Liu
    • 1
  • Gang Liu
    • 1
  • Nanping Yang
    • 1
  • Geng Yin
    • 1
  1. 1.Department of Rheumatology and ImmunologyWest China Hospital of Sichuan UniversityChengduChina

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