Multiple bone fracture due to Fanconi’s syndrome in primary Sjögren’s syndrome complicated with organizing pneumonia
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A 66-year-old woman showing renal dysfunction with elevated serum alkaline phosphatase and anti-SS-A antibody was admitted. A labial salivary gland biopsy showing infiltration of mononuclear cells and positive anti-SS-A antibody with sicca symptoms led to a diagnosis of primary Sjögren’s syndrome (SS). Fanconi’s syndrome was diagnosed by renal tubular acidosis along with renal glucosuria or aminoaciduria and multiple bone fractures on bone scintigraphy. Typical bilateral pulmonary shadows were confirmed as organizing pneumonia (OP) determined by the analysis of bronchoalveolar lavage fluid and transbronchial lung biopsy. A rare complication of Fanconi’s syndrome with OP in SS is described.
KeywordsSjögren’s syndrome Multiple bone fractures Fanconi’s syndrome Renal tubular acidosis Organizing pneumonia
Bronchoalveolar lavage fluid
Renal tubular acidosis
- 6.Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al (2002) Classification criteria for Sjögren’s syndrome: a Revised Version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554–558. doi: 10.1136/ard.61.6.554 CrossRefPubMedGoogle Scholar
- 12.Furukawa M, Sakamoto A, Kita Y, Ohishi Y, Matsumura R, Tsubata R et al (1996) T-cell receptor repertoire of infiltrating T cells in lachrymal glands, salivary glands and kidneys from alymphoplasia (aly) mutant mice: a new model for Sjögren’s syndrome. Br J Rheumatol 35:1223–1230. doi: 10.1093/rheumatology/35.12.1223 CrossRefPubMedGoogle Scholar