Rheumatology International

, 29:1463 | Cite as

Systemic lupus erythematosus in Egyptian children

  • Samia Salah
  • Hala Mohamed Lotfy
  • Samar M. Sabry
  • Azza El Hamshary
  • Heba Taher
Original Article


The aim of the study was to study the characteristics of systemic lupus erythematosus (SLE) in the Egyptian population, comparing it to other populations. We retrospectively studied 207 patients with SLE diagnosed between 1990 and 2005. We obtained clinical features and laboratory data and analyzed them statistically. We studied 151 female and 56 male SLE patients. The female to male ratio was 2.7 to 1 and the mean age at presentation was 10 ± 2.7 years (range 2–16). The mean disease duration was 6.47 ± 3.74 years. At diagnosis, musculoskeletal, constitutional and mucocutaneous manifestations were the commonest features. During follow-up, the prevalence of nephritis (67%), hematological manifestations (44.9%), photosensitivity (44%), arthritis (39%), malar rash (38.2%), serositis (32.9%) and neuropsychiatric manifestations (24.25%) increased significantly. Those whose age of onset of the disease was ≤5 years (nine patients) had significantly more common hematological affection (P value = 0.0005). The characteristics of SLE in Egyptian patients show some similarities to other series of Middle Eastern countries, but with a lower female to male ratio. Disease onset below 5 years is extremely rare (4.35%), commonly presenting with hematological manifestations. The kidney was the commonest major internal organ involved, and also an important cause of death.


Systemic lupus erythematosus Lupus epidemiology Egyptian children 



We extens our special thanks to all the members of the Rheumatology Clinic, who helped us in our work, and to all the children, who participated in conducting the study.

Conflict of interest statement



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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Samia Salah
    • 1
  • Hala Mohamed Lotfy
    • 1
  • Samar M. Sabry
    • 1
  • Azza El Hamshary
    • 1
  • Heba Taher
    • 1
  1. 1.Cairo University HospitalCairoEgypt

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