Rheumatology International

, Volume 29, Issue 11, pp 1323–1326

Clinical and serological correlates of anti-Sm autoantibodies in Chinese patients with systemic lupus erythematosus: 1,584 cases

  • Jin Dong Ni
  • Xi Yao
  • Hai Feng Pan
  • Xiang Pei Li
  • Jian Hua Xu
  • Dong Qing Ye
Original Paper

DOI: 10.1007/s00296-009-0855-1

Cite this article as:
Ni, J.D., Yao, X., Pan, H.F. et al. Rheumatol Int (2009) 29: 1323. doi:10.1007/s00296-009-0855-1

Abstract

To investigate the association of anti-Sm antibodies with clinical and serological features in systemic lupus erythematosus. A group of 1,584 patients with SLE was recruited. Clinical and laboratory data were compared between patients with and without anti-Sm antibodies. There were 1,424 females and 160 males, the mean age of the patients was 33.2 ± 12.3 years, and the mean duration of disease was 32.5 ± 59.4 months. A total of 469 (29.6%) were anti-Sm antibodies positive. The presence of anti-Sm antibodies was associated with arthritis, renal involvement, malar rash, vasculitis and low serum complement C3. The positive rate of anti-nuclear, anti-dsDNA, anti-La/SSB and anti-U1RNP antibodies were significant higher in anti-Sm positive group when compared with anti-Sm negative group. A trend towards a higher presence of anti-Sm antibodies related to an early disease onset was observed. In conclusion, Anti-Sm antibodies are associated with lupus related clinical and laboratory profiles and correlated significantly with disease activity.

Keywords

Anti-Sm Autoantibodies China Clinical feature Systemic lupus erythematosus 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jin Dong Ni
    • 1
  • Xi Yao
    • 2
  • Hai Feng Pan
    • 2
  • Xiang Pei Li
    • 3
  • Jian Hua Xu
    • 4
  • Dong Qing Ye
    • 2
  1. 1.Department of Epidemiology and BiostatisticsSchool of Public Health, Guangdong Medical CollegeDongguanChina
  2. 2.Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical UniversityHefeiChina
  3. 3.Department of RheumatologyAnhui Provincial HospitalHefeiChina
  4. 4.Department of Rheumatology, First Affiliated HospitalAnhui Medical UniversityHefeiChina

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