Rheumatology International

, Volume 29, Issue 11, pp 1315–1321 | Cite as

Antibody against mutated citrullinated vimentin: a new sensitive marker in the diagnosis of rheumatoid arthritis

  • Ernst Wagner
  • M. Skoumal
  • P. M. Bayer
  • K. Klaushofer
Original Paper

Abstract

The aim of this study was to determine the performance of antibodies against mutated citrullinated vimentin (anti-MCV) in comparison with antibodies to cyclic citrullinated peptides (anti-CCP) in patients with rheumatoid arthritis (RA). Serum levels of anti-MCV and anti-CCP were determined in 193 patients with RA and 332 controls, and sensitivity and specificity were calculated. In a separate analysis of 86 patients, the anti-MCV levels were compared to disease activity. Sensitivity of anti-MCV versus anti-CCP was 71.5 and 69.4%, specificity was 81.3 and 97.6%, respectively. The ROC curves showed higher specificity and an advantage of anti-CCP. In seronegative RA patients the sensitivity of anti-MCV was superior over anti-CCP. Anti-MCV positivities also occurred in systemic lupus erythematosus and Sjoegren’s syndrome. In a subgroup of 86 RA patients we found a significant correlation between anti-MCV and disease activity. Anti-MCV appears to be an important marker for the diagnosis of RA, and correlates also with disease activity.

Keywords

Anti-mutated citrullinated vimentin Rheumatoid arthritis Inflammatory rheumatic diseases Sensitivity and specificity 

Abbreviations

ACR

American College of Rheumatology

ACPA

Anti-citrullinated peptides antibodies

Anti-CCP

Antibodies against cyclic citrullinated peptide

Anti-MCV

Antibodies against mutated citrullinated vimentin

Anti-Sa

Antibodies against Sa-antigen

CRP

C-reactive protein

DAS

Disease activity score

ELISA

Enzyme linked immuno sorbent assay

HLA-DR4

Human leucocyte antigen

RA

Rheumatoid arthritis

RF

Rheumatoid factor

ROC-curve

Receiver operating characteristics curve

SLE

Systemic lupus erythematosus

Notes

Acknowledgments

D.I. Fabian (Orgentech Company) provided the kits for analysis. Funding for this work was given by Ludwig Boltzmann Cluster (Rheumatology, Balneology and Rehabilitation), Institute of Rheumatology of the Kurstadt Baden, Austria.

Conflict of interest statement

The authors declare that they do not have competing interests.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Ernst Wagner
    • 1
  • M. Skoumal
    • 2
  • P. M. Bayer
    • 3
  • K. Klaushofer
    • 4
  1. 1.Institute for Rheumatology of the Kurstadt Baden RSKA Baden of the NOEGKK and Ludwig Boltzmann Cluster Rheumatology, Balneology and RehabilitationForschungsstelle for Epidemiology of Rheumatic DiseasesBadenAustria
  2. 2.Institute for Rheumatology of the Kurstadt Baden 4th Medical Department and Ludwig Boltzmann Institute of Osteology, Hanusch Krankenhaus of WGKKViennaAustria
  3. 3.Central LaboratoryWilhelminen HospitalViennaAustria
  4. 4.4th Medical Department and Ludwig Boltzmann Institute of Osteology, Hanusch Krankenhaus of WGKK and AUVA Trauma Centre MeidlingViennaAustria

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