The aim of this cross-sectional study was to evaluate the frequency of intestinal inflammation and its association with disease activity, functional status and quality of life in patients with ankylosing spondylitis (AS). A total of 25 patients with AS had undergone ileocolonoscopy and concomitant histological study. Clinical and demographical parameters, BASDAI, BASFI, and SF-36 scores were compared between patients with and without macroscopic gut inflammation (MGI). Colonoscopic study revealed MGI in 9 patients and macroscopically normal gut mucosa in 16 patients. On histological examination, of 25 patients 20 had gut inflammation, mostly in ileum. BASDAI score was higher (P < 0.05), SF-36 pain and physical scores, and chest expansion measurement were lower (P = 0.00, P = 0.01, P = 0.01), duration of morning stiffness was longer (P = 0.01) in patients with MGI. Serum C-reactive protein, erytrocyte sedimentation rate levels were similar between groups (P > 0.05). There is high prevalence of histological gut inflammation in AS patients. More active disease should suggest gut inflammation in AS patients.
Ankylosing spondylitis Disease activity Gut inflammation
This is a preview of subscription content, log in to check access.
Calin A, Garrett S, Whitelock H et al (1994) A new approach to defining functional ability in anklosing spondylitis: the development of the bath anklosing spondilitis functional index. J Rheumatol 21:2281–2285PubMedGoogle Scholar
Falkenbach A, Franke A, van der Linden S (2003) Factors associated with body function and disability in patients with ankylosing spondylitis: a cross-sectional study. J Rheumatol 30:2186–2192PubMedGoogle Scholar
Mielants H, Veys EM, Goethals K et al (1991) Gut inflammation in the spondyloarthropathies:clinical, radiological, biologic and genetic features in relation to the type of histology. A prospective study. J Rheumatol 18(10):1542–1551PubMedGoogle Scholar
De Vos M, Cuvelier C, Mielants H et al (1990) Iliocolonoscopy in seronegative spondylarthropathy. Gastroenterology 98(4):1105–1106Google Scholar
Mielant H, Veys EM (1996) Significance of intestinal inflammation in the pathogenesis of spondyloarthropathies. Verh K Acad Geneeskd Belg 58(2):93–116Google Scholar
Smale S, Natt RS, Orchard TR, Russell AS, Bjarnason I (2001) Inflammatory bowel disease and spondylarthropathy. Arthritis Rheum 44:2728–2736. doi:10.1002/1529-0131(200112)44:12<2728::AID-ART459>3.0.CO;2-8PubMedCrossRefGoogle Scholar