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Rheumatology International

, Volume 29, Issue 7, pp 755–758 | Cite as

Association of macroscopic gut inflammation with disease activity, functional status and quality of life in ankylosing spondylitis

  • Gulen Hascelik
  • Bengi OzEmail author
  • Nese Olmez
  • Asuman Memis
  • Gazi Yoruk
  • Belkıs Unsal
  • Nese Ekinci
Original Article

Abstract

The aim of this cross-sectional study was to evaluate the frequency of intestinal inflammation and its association with disease activity, functional status and quality of life in patients with ankylosing spondylitis (AS). A total of 25 patients with AS had undergone ileocolonoscopy and concomitant histological study. Clinical and demographical parameters, BASDAI, BASFI, and SF-36 scores were compared between patients with and without macroscopic gut inflammation (MGI). Colonoscopic study revealed MGI in 9 patients and macroscopically normal gut mucosa in 16 patients. On histological examination, of 25 patients 20 had gut inflammation, mostly in ileum. BASDAI score was higher (P < 0.05), SF-36 pain and physical scores, and chest expansion measurement were lower (P = 0.00, P = 0.01, P = 0.01), duration of morning stiffness was longer (P = 0.01) in patients with MGI. Serum C-reactive protein, erytrocyte sedimentation rate levels were similar between groups (P > 0.05). There is high prevalence of histological gut inflammation in AS patients. More active disease should suggest gut inflammation in AS patients.

Keywords

Ankylosing spondylitis Disease activity Gut inflammation 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Gulen Hascelik
    • 1
  • Bengi Oz
    • 1
    Email author
  • Nese Olmez
    • 1
  • Asuman Memis
    • 1
  • Gazi Yoruk
    • 1
  • Belkıs Unsal
    • 1
  • Nese Ekinci
    • 1
  1. 1.Ataturk Training and Research HospitalIzmirTurkey

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