Rheumatology International

, Volume 29, Issue 1, pp 17–22 | Cite as

Dercum’s disease (Lipomatosis dolorosa): successful therapy with pregabalin and manual lymphatic drainage and a current overview

  • Uwe Lange
  • Peter Oelzner
  • Christine Uhlemann
Original Article


Dercum’s disease which is also termed lipomatosis dolorosa is a rare and relatively unknown disease. In this entity the upper arms, elbows, stomach wall, buttocks, thighs and knees are predominantly affected showing painful subcutaneous adipose tissue deposits. In addition severe hyperalgesia can be triggered by light pressure and touch. Analgesic and/or nonsteroidal antirheumatic drugs have usually only a minor or no effect. Here, we report a patient with Dercum’s disease who was successfully treated with pregabalin and manual lymphatic drainage, and present a current overview of the literature.


Dercum’s disease Lipomatosis dolorosa Pregabalin Manual lymphatic drainage 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Kerckhoff-ClinicBad NauheimGermany
  2. 2.Medical Clinic III, Department of Rheumatology and OsteologyUniversity of JenaJenaGermany
  3. 3.Medical Clinic II, Centrum of nature cureUniversity of JenaJenaGermany

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