Rheumatology International

, 29:43 | Cite as

Human leukocyte antigen-B*2705 is the predominant subtype in the Korean population with ankylosing spondylitis, unlike in other Asians

  • Sang-Hoon Lee
  • In-Ah Choi
  • Yeon-Ah Lee
  • Eun-Kyung Park
  • Young-Hoon Kim
  • Kyoung-Soo Kim
  • Seung-Jae Hong
  • Myung Chul Yoo
  • Hyung-In Yang
Original Article


This study was performed to investigate the frequency of human leukocyte antigen (HLA)-B27 subtypes in the Korean population with spondyloarthropathy (SpA). We determined the HLA subtypes of 267 SpA patients who were positive for the B27 antigen (as determined by serology) by using a PEL-FREEZ kit (Dynal Biotech, Wisconsin, USA). Clinical features, including sex, peripheral joint involvement, and the presence of uveitis, were analyzed in a retrospective cohort study. Among 267 patients, 244 were B*2705-positive and 22 were B*2704-positive. One patient was positive for B*2704/2705. No other subtype was observed among the analyzed patients. We found that HLA-B*2705 was the predominant subtype in Koreans with SpA; this finding is remarkable because other Asians such as the Han or the Japanese exclusively have the B*2704 subtype. This result suggests that the clinical features and prevalence of SpA in Koreans may be similar to those observed in Europeans.


HLA-B27 Korea Subtype Ankylosing Spondylitis Spondyloarthropathy 



This study was supported by an Oriental Medicine Research Center for Bone and Joint Disease grant from the Ministry of Health and Welfare of the Republic of Korea (03-PJ9-PG6-SO01-0002).


  1. 1.
    Johnsen K, Gran JT, Dale K, Husby G (1992) The prevalence of ankylosing spondylitis among Norwegian Samis (Lapps). J Rheumatol 19:1591–1594PubMedGoogle Scholar
  2. 2.
    Braun J, Bollow M, Remlinger G, Eggens U, Rudwaleit M, Distler A, Sieper J (1998) Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors. Arthritis Rheum 41:58–67PubMedCrossRefGoogle Scholar
  3. 3.
    Sieper J, Rudwaleit M (2005) How early should ankylosing spondylitis be treated with tumour necrosis factor blockers? Ann Rheum Dis 64(Suppl 4):iv61–64PubMedCrossRefGoogle Scholar
  4. 4.
    Shankarkumar U, Ghosh K, Mohanty D (2002) HLA B27 polymorphism in Western India. Tissue Antigens 60:98–101PubMedCrossRefGoogle Scholar
  5. 5.
    Cipriani A, Rivera S, Hassanhi M, Márquez G, Hernández R, Villalobos C, Montiel M (2003) HLA-B27 subtypes determination in patients with ankylosing spondylitis from Zulia, Venezuela. Hum Immunol 64:745–749PubMedCrossRefGoogle Scholar
  6. 6.
    Marsh SG (2002) Nomenclature for factors of the HLA system, update April 2002. Hum Immunol 63:795–796PubMedCrossRefGoogle Scholar
  7. 7.
    Khan MA(1998) Spondyloarthropathies. Curr Opin Rheumatol 10:279–281Google Scholar
  8. 8.
    Khan MA (1995) HLA-B27 and its subtypes in world populations. Curr Opin Rheumatol 7:263–269PubMedCrossRefGoogle Scholar
  9. 9.
    Reveille JD, Ball EJ, Khan MA (2001) HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr Opin Rheumatol 13:265–272PubMedCrossRefGoogle Scholar
  10. 10.
    Chou CT, Chen JM, Hsu CM, Chen SJ (2003) HLA-B27 and its subtypes in 4 Taiwanese Aborigine tribes: a comparison to Han Chinese patients with ankylosing spondylitis. J Rheumatol 30:321–325PubMedGoogle Scholar
  11. 11.
    Roh EY, Park S, Kim HS, Park H, Lim YM, Han BY, Park MH (2003) Analysis of Ambiguities of HLA-B Typing using the Dynal RELI SSO HLA-B Test and Development of an interpretation Program for Koreans. Korean J Lab Med 23:268–278Google Scholar
  12. 12.
    Feltkamp TE, Mardjuadi A, Huang F, Chou CT (2001) Spondyloarthropathies in eastern Asia. Curr Opin Rheumatol 13:285–290PubMedCrossRefGoogle Scholar
  13. 13.
    Mw H, Yj C (1999) HLA-B27 subtypes in Korean Patients with Ankylosing Spondylitis by polymerase chain reaction-sequence specific primers (PCR-SSP) Method. Korean J Clin Pathol 19:92–97Google Scholar
  14. 14.
    Bunce M, O’Neill CM, Barnardo MC, Krausa P, Browning MJ, Morris PJ, Welsh KI (1995) Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 46:355–367PubMedCrossRefGoogle Scholar
  15. 15.
    Olerup O, Zetterquist H (1992) HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 39:225–235PubMedGoogle Scholar
  16. 16.
    Kanga U, Mehra NK, Larrea CL, Lardy NM, Kumar A, Feltkamp TE (1996) Seronegative spondyloarthropathies and HLA-B27 subtypes: a study in Asian Indians. Clin Rheumatol 15(Suppl 1):13–18PubMedGoogle Scholar
  17. 17.
    López-Larrea C, Sujirachato K, Mehra NK, Chiewsilp P, Isarangkura D, Kanga U, Dominguez O, Coto E, Penã M, Setién F et al (1995) HLA-B27 subtypes in Asian patients with ankylosing spondylitis. Evidence for new associations. Tissue Antigens 45:169–176PubMedCrossRefGoogle Scholar
  18. 18.
    Nasution AR, Mardjuadi A, Kunmartini S, Suryadhana NG, Setyohadi B, Sudarsono D, Lardy NM, Feltkamp TE (1997) HLA-B27 subtypes positively and negatively associated with spondyloarthropathy. J Rheumatol 24:1111–1114PubMedGoogle Scholar
  19. 19.
    Ma HJ, Hu FP (2006) Diversity of human leukocyte antigen-B27 alleles in Han population of Hunan province, southern China. Tissue Antigens 68:163–166PubMedCrossRefGoogle Scholar
  20. 20.
    Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Geraghty DE, Hansen JA, Mach B, Mayr WR, Parham P, Petersdorf EW, Sasazuki T, Schreuder GM, Strominger JL, Svejgaard A, Terasaki PI (2002) Nomenclature for factors of the HLA system. Hum Immunol 63:1213–1268PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Sang-Hoon Lee
    • 1
  • In-Ah Choi
    • 1
  • Yeon-Ah Lee
    • 1
  • Eun-Kyung Park
    • 2
  • Young-Hoon Kim
    • 2
  • Kyoung-Soo Kim
    • 2
  • Seung-Jae Hong
    • 1
  • Myung Chul Yoo
    • 3
  • Hyung-In Yang
    • 1
    • 4
  1. 1.Department of Rheumatology, College of MedicineKyung Hee UniversitySeoulSouth Korea
  2. 2.East–West Bone and Joint Research CenterKyung Hee University East-West Neo Medical CenterSeoulSouth Korea
  3. 3.Department of Orthopedic Surgery, College of MedicineKyung Hee UniversitySeoulSouth Korea
  4. 4.Department of Internal MedicineKyung Hee University College of MedicineSeoulSouth Korea

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