Rheumatology International

, Volume 28, Issue 6, pp 585–591 | Cite as

Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity

  • Bożena Targońska-Stępniak
  • Maria Majdan
  • Magdalena Dryglewska
Original Article

Abstract

Leptin is a peptide hormone with the tertiary structure of a cytokine, which not only regulates body weight by inhibiting food intake, but also modulates inflammatory and immune responses. The aim of the study was to investigate if there are connections between leptin concentrations and parameters of nutritional status and disease activity in a group of rheumatoid arthritis (RA) patients. The study group consisted of 37 patients. The mean leptin serum concentration was significantly higher in women than in men. The leptin concentrations correlated positively with BMI only in women with RA. The leptin concentrations were significantly higher in patients with erosive RA. Assessing the group of patients with long-standing RA (duration > 10 years), we found that leptin levels were significantly higher in patients with higher disease activity than in those with DAS28 ≤ 5,1; there was also a positive correlation between serum leptin concentration and the value of DAS28, ESR and the number of tender joints. The results suggest that some important dependence exists between the risk of aggressive course of RA and increased leptin levels.

Keywords

Adipocytokines Rheumatoid arthritis Nutritional status Disease activity 

References

  1. 1.
    Walsmith J, Roubenoff R (2002) Cachexia in rheumatoid arthritis. Int J Cardiol 85:89–99PubMedCrossRefGoogle Scholar
  2. 2.
    Walsmith J, Abad L, Kehayias J, Roubenoff R (2004) Tumor necrosis factor-α production is associated with less body mass in women with rheumatoid arthritis. J Rheumatol 31:23–29PubMedGoogle Scholar
  3. 3.
    Otero M, Lago R, Gómez R, Lago F, Dieguez C, Gómez-Reino JJ, Gualillo O (2006) Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 65:1198–1201PubMedCrossRefGoogle Scholar
  4. 4.
    Escalante A, Haas RW, del Rincon I (2005) Paradoxical effect of body mass index on survival in rheumatoid arthritis. Arch Intern Med 165:1624–1629PubMedCrossRefGoogle Scholar
  5. 5.
    Otero M, Lago R, Gómez R, Lago F, Gómez-Reino JJ, Gualillo O (2006) Leptin: a metabolic hormone that functions like a proinflammatory adipokine. Drug News Perspect 19:21–26PubMedCrossRefGoogle Scholar
  6. 6.
    Šenolt L, Housa D, Vernerová Z, Jirásek T, Svobodová R, Veigl D, Anderlová K, Müller-Ladner U, Pavelka K, Haluzik M (2007) Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis 66:458–463PubMedGoogle Scholar
  7. 7.
    Gunaydin R, Kaya T, Atay A, Olmez N, Hur A, Koseoglu M (2006) Serum leptin levels in rheumatoid arthritis and relationship with disease activity. South Med J 99:1078–1083PubMedGoogle Scholar
  8. 8.
    Majdan M, Kotarski J, Książek A (1999) Evaluation of the relationship between possible control of anemia in hemodialysis patients and the concentration of leptin. Pol Arch Med Wewn 101:295–300PubMedGoogle Scholar
  9. 9.
    Meyers JA, McTiernan A, Ulrich CM (2005) Leptin and immune function: integrating the evidence. Nutr Res 25:791–803CrossRefGoogle Scholar
  10. 10.
    Otero M, Lago R, Lago F, Casanueva FF, Dieguez C, Gómez-Reino JJ, Gualillo O (2005) Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 579:295–301PubMedCrossRefGoogle Scholar
  11. 11.
    Bernotiene E, Palmer G, Gabay C (2006) The role of lepin in innate and adaptive immune response. Arthritis Res Ther 8:217–226PubMedCrossRefGoogle Scholar
  12. 12.
    Wisłowska M, Rok M, Jaszczyk B, Stępień K, Cicha M (2007) Serum leptin in rheumatoid arthritis. Rheumatol Int 27:947–954PubMedCrossRefGoogle Scholar
  13. 13.
    Bełtowski J (2006) Leptin and atherosclerosis. Atherosclerosis 189:47–60PubMedCrossRefGoogle Scholar
  14. 14.
    Palmer G, Gabay C (2003) A role for leptin in rheumatic diseases? Ann Rheum Dis 62:913–915PubMedCrossRefGoogle Scholar
  15. 15.
    Busso N, So A, Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D, Gabay C (2002) Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168:875–882PubMedGoogle Scholar
  16. 16.
    Fraser DA, Thoen J, Reseland JE, Forre O, Kjeldsen-Kragh J (1999) Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation. Clin Rheumatol 18:394–401PubMedCrossRefGoogle Scholar
  17. 17.
    Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324PubMedCrossRefGoogle Scholar
  18. 18.
    Steinbrocker O, Treger H, Cornelius H (1949) Therapeutic criteria in rheumatoid arthritis. JAMA 140:659–662Google Scholar
  19. 19.
    Mangge H, Liebmann P, Tanil H, Herrmann J, Wagner C, Gallistl S, Schauenstein K, Erwa W (2000) Cystatin C, an early indicator for incipient renal disease in rheumatoid arthritis. Clin Chim Acta 300:195–202PubMedCrossRefGoogle Scholar
  20. 20.
    Buettner R, Bollheimer LC, Zietz B, Drobnik W, Lackner K, Schmitz G, Schölmerick J, Palitzsch KD (2002) Definition and characterization of relative hypo- and hyperleptinemia in a large Caucasian population. J Endocrinol 175:745–756PubMedCrossRefGoogle Scholar
  21. 21.
    Anders H, Rihl M, Heufelder A, Loch O, Schattenkirchner M (1999) Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis. Metabolism 48:745–748PubMedCrossRefGoogle Scholar
  22. 22.
    Nishiya K, Nishiyama M, Chang A, Shinto A, Hashimoto K (2002) Serum leptin levels in patients with rheumatoid arthritis are correlated with body mass index. Rinsho Byori 50:524–527PubMedGoogle Scholar
  23. 23.
    Popa C, Netea MG, Radstake TRDS, van Riel PL, Barrera P, van der Meer JWM (2005) Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis. Ann Rheum Dis 64:1195–1198PubMedCrossRefGoogle Scholar
  24. 24.
    Hizmetli S, Kisa M, Gokalp N, Bakici MZ (2007) Are plasma and synovial fluid leptin levels correlated with disease activity in rheumatoid arthritis? Rheumatol Int 27:335–338PubMedCrossRefGoogle Scholar
  25. 25.
    Tokarczyk-Knapik A, Nowicki M, Wyroślak J (2002) The relation between plasma leptin concentration and body fat mass in patients with rheumatoid arthritis. Pol Arch Med Wewn 108:761–767PubMedGoogle Scholar
  26. 26.
    Bokarewa M, Bokarew D, Hultgren O, Tarkowski A (2003) Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann Rheum Dis 62:952–956PubMedCrossRefGoogle Scholar
  27. 27.
    Toussirot E, Nguyen NU, Dumoulin G, Aubin F, Cedoz JP, Wendling D (2005) Relationship between growth hormone-IGF-1–IGFBP-3 axis and serum leptin levels with bone mass and body composition in patients with rheumatoid arthritis. Rheumatology (Oxford) 44:120–125CrossRefGoogle Scholar
  28. 28.
    Salazar-Paramo M, Gonzalez-Ortiz M, Gonzalez-Lopez L, Sanchez-Ortis A, Valera-Gonzalez IC, Martinez-Abundis E, Balcazar-Munoz BR, Garcia-Gonzalez A, Gamez-Nava JI (2001) Serum leptin levels in patients with rheumatoid arthritis. J Clin Rheumatol 7:57–59PubMedCrossRefGoogle Scholar
  29. 29.
    Hörle P, Sarzi-Puttini P, Cutolo M, Straub RH (2006) No change of serum levels of leptin and adiponectin during anti-tumor necrosis factor antibody treatment with adalimumab in patients with rheumatoid arthritis. Ann Rheum Dis 65:970–971CrossRefGoogle Scholar
  30. 30.
    Bruun JM, Pedersen SB, Kristensen K, Richelsen B (2002) Effects of proinflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Mol Cel Endocrinol 190:91–99CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Bożena Targońska-Stępniak
    • 1
  • Maria Majdan
    • 1
  • Magdalena Dryglewska
    • 1
  1. 1.Department of Rheumatology and Connective Tissue DiseasesMedical University of LublinLublinPoland

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