Rheumatology International

, Volume 28, Issue 6, pp 597–600

Primary hypertrophic osteoarthropathy with myelofibrosis

Case Report

Abstract

Primary hypertrophic osteoarthropathy or pachydermoperiostosis is a rare congenital disease characterized by clubbing of the fingers, periostitis of the distal long bones, and hypertrophic skin changes (pachydermia) including thick folds in the skin of the face, forehead, scalp and extremities, and also joint pain. Clinical manifestations of this disease generally appear among the young and middle-aged. In this article we report a case of a 43-year-old man with pachydermoperiostosis. His skin and joint manifestations were prominent. He had also anemia, and bone marrow biopsy showed myelofibrosis.

Keywords

Pachydermoperiostosis Primary hypertrophic osteoarthopathy Cutis verticis gyrata Digital clubbing Myelofibrosis 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Massoud Saghafi
    • 1
    • 4
  • Azita Azarian
    • 2
  • Najmeh Nohesara
    • 3
  1. 1.Department of Rheumatology, Ghaem HospitalMashhad UniversityMashhadIran
  2. 2.Department of Radiology, Ghaem HospitalMashhad UniversityMashhadIran
  3. 3.Ghaem HospitalMashhad UniversityMashhadIran
  4. 4.Department of MedicineGhaem HospitalMashhadIran

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