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Rheumatology International

, Volume 28, Issue 2, pp 161–165 | Cite as

The association of DRB1*04 share epitope alleles and tumor necrosis factor-alpha gene polymorphism (−863) with susceptibility to rheumatoid arthritis in Thai

  • N. HirankarnEmail author
  • J. Nakkuntod
  • P. Duangchalermwong
  • U. Deesomchok
  • P. Charoenwongse
Original Article

Abstract

Rheumatoid arthritis (RA) in Thai population is significantly associated with HLA-DR4 shared epitope (SE) alleles, particularly with DRB1*0405 (P = 0.00004, OR = 3.84, 95% CI = 1.93, 7.7). In addition, tumor necrosis factor-alpha (TNF-alpha) gene −863A alleles were found to be significantly increased in 77 RA patients compared to 162 healthy controls (P = 0.03, OR = 1.73, 95% CI = 1.05, 2.87). Interestingly, TNF-863 AC and SE have a synergistic effect on the susceptibility to RA. The OR for the presence of both risk factors (DR4 SE and −863 AC) was cumulative: 15.4 (95% CI = 3.75, 73.6) while the separate OR of DR4 SE and −863 AC were 3.84 and 2.36, respectively. The TNF was not associated with the clinical manifestation and severity of Thai RA patients. However, a highly significant association was found between RF positivity, one marker for severity, and RA patients with DR4 SE (P = 0.0005, OR = 9.42, 95% CI = 2.26, 45.27).

Keywords

HLA-DR4 Polymorphism Rheumatoid arthritis Tumor necrosis factor 

Notes

Acknowledgments

The authors are deeply indebted to the staff of the Rheumatology Unit, Department of Medicine, Chulalongkorn University for the recruitment of patients. This work was supported by the Lupus Research Unit, Chulalongkorn University.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • N. Hirankarn
    • 1
    Email author
  • J. Nakkuntod
    • 1
  • P. Duangchalermwong
    • 2
  • U. Deesomchok
    • 2
  • P. Charoenwongse
    • 1
  1. 1.Lupus Research Unit and Department of Microbiology, Faculty of MedicineChulalongkorn UniversityBangkokThailand
  2. 2.Department of Medicine, Faculty of MedicineChulalongkorn UniversityBangkokThailand

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