Rheumatology International

, Volume 28, Issue 2, pp 137–143

Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis

  • Yasunori Kageyama
  • Tetsuya Ichikawa
  • Tetsuyuki Nagafusa
  • Eiji Torikai
  • Masahiro Shimazu
  • Akira Nagano
Original Article


The purpose of this study was to analyze the effect of the soluble TNF-α receptor etanercept on the serum levels of IL-16, IL-17, IL-23, and macrophage inflammatory protein-3α (MIP-3α) in rheumatoid arthritis (RA) patients. Twenty-two patients with RA were administered etanercept once or twice a week for more than 6 months, and we evaluated clinical and laboratory parameters and serum levels of IL-16, IL-17, IL-23, and MIP-3α at the baseline and at 3 and 6 months. Additionally, the production of IL-23 and MIP-3α of cultured synovial cells stimulated with TNF-α from RA patients was determined by ELISA. We also used ELISA kits to determine synovial fluid (SF) levels of IL-17, IL-23, and MIP-3α in patients with RA, osteoarthritis (OA), pseudogouty arthritis (PGA), and gouty arthritis (GA). A significant decrease in serum levels of IL-23 and MIP-3α was observed at 3 and 6 months after initial treatment of etanercept. TNF-α induced MIP-3α but not IL-23 production in cultured synovial cells from RA patients. SF levels of IL-17, IL-23, and MIP-3α in RA patients showed significantly higher levels than those of OA, PGA, and GA patients. This study demonstrated that the reduction of IL-23 and MIP-3α production in RA patients was a newly determined function of etanercept


Etanercept Rheumatoid arthritis IL-23 MIP-3α 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Yasunori Kageyama
    • 1
  • Tetsuya Ichikawa
    • 1
  • Tetsuyuki Nagafusa
    • 1
  • Eiji Torikai
    • 1
  • Masahiro Shimazu
    • 1
  • Akira Nagano
    • 1
  1. 1.Department of Orthopaedic SurgeryHamamatsu University School of MedicineHamamatsuJapan

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