Rheumatology International

, Volume 27, Issue 11, pp 1087–1089 | Cite as

Nephrotic syndrome as a clinical manifestation of systemic sclerosis

  • Ewa WieloszEmail author
  • Maria Majdan
  • Dorota Suszek
  • Iwona Smarz-Widelska
  • Agnieszka Korolczuk
  • Elżbieta Korobowicz
Case Report


We have described the unusual case of coexistence of membranous nephropathy resulting in nephrotic syndrome with systemic sclerosis. A 60-year-old patient was admitted to the Department of Nephrology with marked proteinuria and oedema. The renal biopsy specimen disclosed the features characteristic of membranous glomerulonephritis. The patient was treated with chlorambucil for 1 month followed by prednisone for 1 month. However, her condition still did not improve. Therefore, the other causes of nephrotic syndrome were investigated. Once anti-Scl-70 antibody was detected the patient was transferred to the Department of Rheumatology and Connective Tissue Diseases. Physical examination revealed Raynaud phenomenon, sclerodactylia, thickened skin of the chest and back. The patient was diagnosed with diffuse systemic sclerosis. The cyclophosphamide therapy was instituted and the patient’s condition improved.


Membranous glomerulonephritis Nephrotic syndrome Renal involvement Systemic sclerosis 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ewa Wielosz
    • 1
    Email author
  • Maria Majdan
    • 1
  • Dorota Suszek
    • 1
  • Iwona Smarz-Widelska
    • 2
  • Agnieszka Korolczuk
    • 3
  • Elżbieta Korobowicz
    • 3
  1. 1.Department of Rheumatology and Connective Tissue DiseasesMedical University of LublinLublinPoland
  2. 2.Department of NephrologyRegional Specialist HospitalLublinPoland
  3. 3.Department of PatomorphologyMedical University of LublinLublinPoland

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