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Rheumatology International

, Volume 27, Issue 11, pp 1091–1093 | Cite as

Seronegative Lyme arthritis

  • A. Holl-Wieden
  • S. Suerbaum
  • H. J. GirschickEmail author
Case Report

Abstract

We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years before and who experienced a flare of arthritis affecting one knee while she was off medication for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of Borrelia burgdorferi DNA in synovial fluid. No humoral immune response to Borrelia burgdorferi was detectable before, at the time of diagnosis and up to 3 years later.

Keywords

Synovial Fluid Juvenile Idiopathic Arthritis Borrelia Burgdorferi Synovial Fluid Sample Tick Bite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

NSAID

Nonsteroidal anti-inflammatory drugs

IAS

Intraarticular corticoid injections

JIA

Juvenile idiopathic arthritis

References

  1. 1.
    Bunikis J, Barbour AG (2002) Laboratory testing for suspected Lyme disease. Med Clin North Am 86:311–340PubMedCrossRefGoogle Scholar
  2. 2.
    Dejmkova H, Hulinska D, Tegzova D, Pavelka K, Gatterova J, Vavlik P (2002) Seronegative Lyme arthritis caused by Borrelia garinii. Clin Rheumatol 21:330–334PubMedCrossRefGoogle Scholar
  3. 3.
    Frossard E, Rutti B, Burgherr J, Godfroid E, Brossard M, Gerber NJ (1999) Nachweis von Borrelien-DNA in der Synovialflüssigkeit zur diagnose der Lyme-arthritis. Schweiz Med Wochenschr 129:979–984PubMedGoogle Scholar
  4. 4.
    Jaulhac B, Chary-Valckenaere I, Sibilia J, Javier RM et al (1996) Detection of Borrelia burgdorferi DNA amplification in synovial tissue samples from patients with Lyme arthritis. Arthritis Rheum 39:736–745PubMedCrossRefGoogle Scholar
  5. 5.
    Massarotti EM (2002) Lyme arthritis. Med Clin North Am 86(2):297–309PubMedCrossRefGoogle Scholar
  6. 6.
    Schutzer SE, Coyle PK, Reid P, Holland B (1999) Borrelia burgdorferi-specific immune complexes in acute Lyme disease. JAMA 282:1942–1946PubMedCrossRefGoogle Scholar
  7. 7.
    Singh SK, Girschick HJ (2004) Lyme borreliosis:from infection to autoimmunity. Clin Microbiol Infect 10:598–614PubMedCrossRefGoogle Scholar
  8. 8.
    Singh SK, Girschick HJ (2004) Molecular survival strategies of the Lyme disease spirochete Borrelia burgdorferi. Lancet Infect Dis 4:575–583PubMedCrossRefGoogle Scholar
  9. 9.
    Singh SK, Girschick HJ (2003) Tick-host interactions and their immunological implications in tick-born disease. Curr Sci 85:1284–1298Google Scholar
  10. 10.
    Steere AC, Coburn J, Glickstein L (2004) The emergence of Lyme disease. J Clin Invest 113:1093–1101PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Children’s hospital, Section of Pediatric Rheumatology, Immunology and Infectious diseasesUniversity of WuerzburgWuerzburgGermany
  2. 2.Institute of Microbiology and HygieneUniversity of WürzburgWuerzburgGermany

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