Rheumatology International

, Volume 27, Issue 11, pp 1091–1093 | Cite as

Seronegative Lyme arthritis

  • A. Holl-Wieden
  • S. Suerbaum
  • H. J. GirschickEmail author
Case Report


We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years before and who experienced a flare of arthritis affecting one knee while she was off medication for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of Borrelia burgdorferi DNA in synovial fluid. No humoral immune response to Borrelia burgdorferi was detectable before, at the time of diagnosis and up to 3 years later.


Synovial Fluid Juvenile Idiopathic Arthritis Borrelia Burgdorferi Synovial Fluid Sample Tick Bite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Nonsteroidal anti-inflammatory drugs


Intraarticular corticoid injections


Juvenile idiopathic arthritis


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Children’s hospital, Section of Pediatric Rheumatology, Immunology and Infectious diseasesUniversity of WuerzburgWuerzburgGermany
  2. 2.Institute of Microbiology and HygieneUniversity of WürzburgWuerzburgGermany

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