Rheumatology International

, Volume 27, Issue 8, pp 743–746 | Cite as

Factors affecting drug treatment compliance in patients with rheumatoid arthritis

  • Reyhan Tuncay
  • Emel Eksioglu
  • Banu Cakir
  • Eda Gurcay
  • Aytul Cakci
Original Article


We prospectively examined 100 rheumatoid arthritis (RA) patients to calculate drug compliance rates, characteristics of compliant and non-compliant patients, and changes in compliance over time. Three assessments were obtained over a one-year follow–up. Detailed drug history of RA and for concomitant disease was queried. Sedimentation rate, C-reactive protein, and rheumatoid factor values, Ritchie articular index, morning stiffness, and health assessment questionnaire were evaluated. Twenty-six patients (30.2%) were consistently compliant and 10 patients (11.6%) were consistently non-compliant. Older age was associated with a greater likelihood of compliance. Comparison of compliant and non-compliant groups revealed no statistically significant difference in distribution of gender, disease duration, and total number of pills taken for RA and/or total number of pills taken for any reason. In conclusion, compliance to drugs in RA patients is a common problem. Clinical and laboratory activity of RA had less influence on drug compliance. Older age is associated with a greater likelihood of compliance.


Drug compliance Rheumatoid arthritis 


  1. 1.
    Vitolins MZ, Rand CS, Rapp SR, Ribisl PM, Sevick MA (2000) Measuring adherence to behavioral and medical interventions. Control Clin Trials 21:188S–194SPubMedCrossRefGoogle Scholar
  2. 2.
    Viller F, Guillemin F, Briancon S, Moum T, Suurmeijer T, van den Heuvel W (1999) Compliance to drug treatment of patients with rheumatoid arthritis: a 3 year longitudinal study. J Rheumatol 26:2114–2122PubMedGoogle Scholar
  3. 3.
    de Klerk E, van der Heide D, Landewe R, van der Tempel H, Urquart J, van der Linden S (2003) Patient compliance in rheumatoid arthritis, polymyalgia rheumatica and gout. J Rheumatol 30:44–54PubMedGoogle Scholar
  4. 4.
    Pullar T, Peaker S, Martin MF, Bırd HA, Feely MP (1988) The use of a pharmacological indicator to investigate compliance in patients with a poor response to antirheumatic therapy. Br J Rheumatol 27:381–384PubMedCrossRefGoogle Scholar
  5. 5.
    Stephenson BJ, Rowe BH, Haynes RB, Macharia WM, Leon G (1993) Is this patient taking the treatment as prescribed? JAMA 269:2779–2781PubMedCrossRefGoogle Scholar
  6. 6.
    Lee P, Tan LJ (1979) Drug compliance in outpatients with rheumatoid arthritis. Aust N Z J Med 9:274–277PubMedGoogle Scholar
  7. 7.
    Kauppi M, Sokka T, Hannonen P (2005) Survey nonresponse is associated with increased mortality in patients with rheumatoid arthritis and in a community population. J Rheumatol 32:807–810PubMedGoogle Scholar
  8. 8.
    Garcia Popa-Lisseanu MG, Greisinger A, Richardson M, O’Malley KJ, Janssen NM, Marcus DM, Tagore J, Svarez-Almazor ME (2005) Determinants of treatment adherence in ethnically diverse, economically disadvantaged patients with rheumatic diseases. J Rheumatol 32:913–919PubMedGoogle Scholar
  9. 9.
    Blackwell B (1972) The drug defaulter. Clin Pharmacol Ther 13:841–848PubMedGoogle Scholar
  10. 10.
    Owen SG, Friesen WT, Roberts MS, Flux W (1985) Determinants of compliance in rheumatoid arthritic patients assessed in their home environment. Br J Rheumatol 24:313–320PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Reyhan Tuncay
    • 1
  • Emel Eksioglu
    • 1
  • Banu Cakir
    • 2
  • Eda Gurcay
    • 1
  • Aytul Cakci
    • 1
  1. 1.Department of Physical Therapy and Rehabilitation Ministry of Health, Ankara Diskapi Yildirim Beyazit Education and Research Hospital AnkaraTurkey
  2. 2.Department of Public Health Hacettepe University, Medical School AnkaraTurkey

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