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Rheumatology International

, Volume 27, Issue 8, pp 695–698 | Cite as

Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis

  • Liora Harel
  • Masha Mukamel
  • Abraham Zeharia
  • Yona Kodman
  • Dario Prais
  • Yosef Uziel
  • John B. Zabriskie
  • Jacob Amir
Original Article

Abstract

An elevated expression of the alloantigen D8/17 on B lymphocytes has been previously proposed as a susceptibility marker in rheumatic fever. The aim of the study was to investigate the presence of the D8/17 marker on B lymphocytes in poststreptococcal reactive arthritis (PSRA). The study sample included 19 patients (15 boys, 4 girls; mean age 11.7 ± 5.4 years) who were diagnosed with PSRA (mean age at diagnosis, 9.4 ± 5.6 years) and 18 healthy controls (10 boys and 8 girls) matched for ethnic background. B-cell D8/17 expression was tested by flow cytometry assay using monoclonal antibodies. Laboratory results showed a higher expression of D8/17 in the patient group (23.1 ± 10.4%, range 11.6–51.9%) than in the control group (17.1 ± 8.2%, range 7.1–35.7) in controls; this difference was statistically significant after log transformation of the data (P = 0.035). The high rate of expression of the D8/17 marker in patients with PSRA suggests that RF and PSRA share the same genetic susceptibility.

Keywords

D8/17 marker Poststreptococcal reactive arthritis Rheumatic fever 

Notes

Acknowledgment

The authors wish to thank Mrs. Phyllis Curchack Kornspan for her editorial and secretarial assistance.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Liora Harel
    • 1
  • Masha Mukamel
    • 2
  • Abraham Zeharia
    • 3
  • Yona Kodman
    • 4
  • Dario Prais
    • 1
  • Yosef Uziel
    • 5
  • John B. Zabriskie
    • 6
  • Jacob Amir
    • 1
  1. 1.Department of Pediatrics C, Schneider Children’s Medical Center of Israel, Petach Tikvah, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.Pediatric Rheumatology Unit, Schneider Children’s Medical Center of Israel, Petach Tikvah, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Ambulatory Care Unit Schneider Children’s Medical Center of Israel, Petach Tikvah, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  4. 4.Department of Hemato-Oncology, Schneider Children’s Medical Center of Israel, Petach Tikvah, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  5. 5.Department of Pediatrics, Sapir Medical Center, Kfar Saba, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  6. 6.Laboratory of Clinical Microbiology/ImmunologyThe Rockefeller UniversityNew YorkUSA

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