Rheumatology International

, Volume 27, Issue 7, pp 683–686 | Cite as

Case report of a patient with osteopoikilosis

  • Münevver Serdaroğlu
  • Erhan Çapkın
  • Faik Üçüncü
  • Mehmet Tosun
Case Report


Osteopoikilosis (OPK) is a benign osteosclerotic dysplasia of unknown origin, which is an inherited autosomal disorder. Males and females are equally affected. It is usually asymptomatic and may only be recognized on radiological examination. In this study we report a 33-year-old woman with fibromyalgia who suffers from back and leg pain and was diagnosed OPK by radiologically and review literature.


Osteopoikilosis Sclerosing bone dysplasia Fibromyalgia 


  1. 1.
    Benli IT, Akalin S, Boysan E, Mumcu EF et al (1992) Epidemiological, clinical and radiological aspects of osteopoikilosis. J Boint Surg 74:504–506Google Scholar
  2. 2.
    Günal I, Seber S, Başaran N et al (1993) Dacryocystitis associated with osteopoikilosis. Clin Genet 44:211–213PubMedCrossRefGoogle Scholar
  3. 3.
    Walker GF (1964) Mixed sclerosing bone dystrophies. Two case reports. J Bone Joint Surg 46:654–552Google Scholar
  4. 4.
    Ostrowski DM, Gilula LA (1992) Mixed sclerosing bone dystrophy presenting with upper extremity deformities. A case report and review of the literature. J Hand Surg 17:108–112Google Scholar
  5. 5.
    Reznick D, Niwayama G (1988) Enostosis, hyperostosis and periostitis. In: Reznick D, Niwayama G (eds) Diagnosis of bone and joint disorders. W.B Saunders Company, Philadelphia, pp 4084–4088Google Scholar
  6. 6.
    Goldenberg DL (2003) Fibromyalgia and related syndromes. In: Textbook of rheumatology, 3rd edn. Mosby, Philadelphia, pp 701–710Google Scholar
  7. 7.
    Chigara M, Kato K, Mashio K, Shinozaki T (1991) Symmetry of bone lesions in osteopoikilosis: a report of four cases. Acta Orthop Scand 62:495–496Google Scholar
  8. 8.
    Green AE, Ellswood WH, Collins JR (1962) Melorheostosis and osteopoikilosis with a review of the literature. AJR 86:1096–1110Google Scholar
  9. 9.
    Lagier R, Mbakop A, Bigler A (1984) Osteopoikilosis: a radiological and pathological study. Skeletal Radiol 11(3):161–168PubMedCrossRefGoogle Scholar
  10. 10.
    Mindell ER, Northup CS, Gouglass HO Jr (1978) Osteosarcoma associated with osteopoikilosis. Case report. J Bone Joint Surg (Am) 60:406–408Google Scholar
  11. 11.
    Vanhoenacker FM, De Beuckeleer LH, Van Hul W et al (2000) Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol 10:1423–1433PubMedCrossRefGoogle Scholar
  12. 12.
    Resnick D (1996) Enostosis, hyperostosis and periostitis. In: Bone and joint imaging. Saunders, Philadelphia, pp 1213–1214Google Scholar
  13. 13.
    Woodrow SL, Pope FM, Handfield-Jones SE (2001) The Buschkle-Ollendorf syndrome presenting as familial elastic tissue naive. Br J Dermatol 144:890–893PubMedCrossRefGoogle Scholar
  14. 14.
    Bicer A, Tursen U, Ozer C, Kaya TI et al (2002) Coexistence of osteopoikilosis and discoid lupus erythematosus: a case report. Clin Rheumatol 21:405–407PubMedCrossRefGoogle Scholar
  15. 15.
    Verbov J (1977) Bushkle-Ollendorff syndrome. (Disseminated dermatofibrosis with osteopoikilosis). Br J Dermatol 96:87–90PubMedCrossRefGoogle Scholar
  16. 16.
    Duke-Elder S (1974) System of ophthalmology, vol 12, 1st edn. Henry Kimpton Publishers, London Google Scholar
  17. 17.
    Weisz GM (1982) Lumbar spinal canal stenosis in osteopoikilosis. Clin Orthop 166:89–92PubMedGoogle Scholar
  18. 18.
    Gunal I, Kıter E (2003) Disorders associated with osteopoikilosis. Acta Orthop Scand 74(4):497–499PubMedCrossRefGoogle Scholar
  19. 19.
    Mungovan JA, Tung GA, Lambiase RE et al (1994) Tc-99m MDP uptake in osteopoikilosis. Clin Nucl Med 19(1):6–8PubMedCrossRefGoogle Scholar
  20. 20.
    Havitcioğlu H, Günal I, Göcen S (1998) Synovial chondromatosis associated with osteopoikilosis; a case report. Acta Orthop Scand 69:649–650PubMedCrossRefGoogle Scholar
  21. 21.
    Middleton GD, McFarlin JE, Lipsky PE (1994) The prevalence and clinic impact of in fibromyalgia in systemic lupus erythematosus. Arthritis Rheum 37:1181–1188PubMedCrossRefGoogle Scholar
  22. 22.
    Bonafede RP, Downey DC, Bennett RM (1995) An association of fibromyalgia with primary Sjögren’s syndrome: a prospective study of 72 patients. J Rheumatol 22:133–136PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Münevver Serdaroğlu
    • 1
  • Erhan Çapkın
    • 1
  • Faik Üçüncü
    • 1
  • Mehmet Tosun
    • 1
  1. 1.Medical Faculty, Physical Therapy & RehabilitationKaradeniz Technical UniversityTrabzonTurkey

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