Rheumatology International

, Volume 27, Issue 4, pp 339–344 | Cite as

Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis

  • Ozlem Altindag
  • Ozcan Erel
  • Nurten Aksoy
  • Sahabettin Selek
  • Hakim Celik
  • Mustafa Karaoglanoglu
Original Article


The purpose of this study was to determine serum oxidative/antioxidative status in patients with knee osteoarthritis and its relation with prolidase activity, which plays an important role in collagen metabolism. Serum antioxidative status was evaluated by measuring total antioxidant capacity (TAC), thiol level and catalase enzyme activity in patients with osteoarthritis and in healthy controls. Serum oxidative status was evaluated by measuring total peroxide (TP) and lipid hydroperoxide. Oxidative stress index (OSI) was calculated. Prolidase enzyme activity was measured to investigate the collagen metabolism. Serum TAC, thiol level, catalase activity and prolidase activity were significantly lower in patients than in controls (P < 0.001, for all). In contrast, TP, lipid hydroperoxide and OSI values were significantly higher in patients than in controls (P < 0.001 for all). Further, prolidase activity was negatively correlated with TP and OSI, and positively correlated with TAC. The present results indicate that the oxidant parameters increased and antioxidant parameters decreased in patients with osteoarthritis; therefore, these patients may be exposed to a potent oxidative stress. Decreased collagen metabolism may be related with oxidative stress, which has a role in the ethiopathogenesis and/or in the progression of the disease.


Antioxidants Osteoarthritis Reactive oxygen species Prolidase 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Ozlem Altindag
    • 1
  • Ozcan Erel
    • 2
  • Nurten Aksoy
    • 2
  • Sahabettin Selek
    • 2
  • Hakim Celik
    • 2
  • Mustafa Karaoglanoglu
    • 3
  1. 1.Department of Physical Medicine and Rehabilitation, Medical Faculty, Research HospitalHarran UniversitySanliurfaTurkey
  2. 2.Department of Biochemistry Harran UniversitySanliurfaTurkey
  3. 3.Department of RadiologyHarran UniversitySanliurfaTurkey

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