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Rheumatology International

, Volume 26, Issue 12, pp 1154–1157 | Cite as

Cutaneous leukocytoclastic vasculitis with cervical tuberculous lymphadenitis: a case report and literature review

  • Hee Man Kim
  • Yong-Beom Park
  • Ho Young Maeng
  • Soo-Kon LeeEmail author
Case Report

Abstract

Cutaneous leukocytoclastic vasculitis (CLV) is a small-vessel vasculitis localized to the skin. Many possible causes exist for this pathological condition, including drugs, infection, collagen vascular disease, and malignancy. However, Mycobacterium tuberculosis is rarely reported to be associated with CLV. Here, we report a 49-year-old male patient that presented with fever, myalgia, and multiple palpable purpura on both of his legs. The biopsy from the purpura yielded a histologic diagnosis of leukocytoclastic vasculitis. The patient had several enlarged lymph nodes on his right neck, and the biopsy revealed tuberculous lymphadenitis. There were no signs of vasculitis present in the internal organs. After anti-tuberculosis treatment, his fever declined and the skin purpura were completely resolved. Although incidence is rare, tuberculosis should be considered as a possible cause of CLV.

Keywords

Leukocytoclastic vasculitis Mycobacterium tuberculosis 

References

  1. 1.
    Ekenstam E, Callen JP (1984) Cutaneous leukocytoclastic vasculitis. Clinical and laboratory features of 82 patients seen in private practice. Arch Dermatol 120:484–489CrossRefGoogle Scholar
  2. 2.
    Charles J, Ronald JF (1997) Small vessel vasculitis. N Engl J Med 20:1512–1523Google Scholar
  3. 3.
    Lacour JP, Castanet J, Perrin C, Vitetta A, Ortone J-P (1993) Cutaneous leukocytoclastic vasculitis and renal cancer: two cases. Am J Med 94:104–108PubMedCrossRefGoogle Scholar
  4. 4.
    Sais G, Vidaller A, Jucgla A, Servitje O, Condom E, Peyri J (1998) Prognostic factors in leukocytoclastic vasculitis. Arch Dermatol 134:309–315PubMedCrossRefGoogle Scholar
  5. 5.
    Bonnefoy M, Claudy AL (1988) Etude prostpective de facteurs associes aux vascularites leucocytoclasiques. Ann Dermatol Venereol 115:27–32PubMedGoogle Scholar
  6. 6.
    Mackel SE, Jordon RE (1982) Leukocytoclastic vasculitis. A cutaneous expression of immune complex disease. Arch Dermatol 118:296–301PubMedCrossRefGoogle Scholar
  7. 7.
    Sams WM Jr (1985) Human hypersensitivity angiitis, an immune complex disease. J Invest Dermatol 85:114s-148s CrossRefGoogle Scholar
  8. 8.
    Mertz LE, Conn DL (1992) Vasculitis associated with malignancy. Curr Opin Rheumatol 4:39–46PubMedGoogle Scholar
  9. 9.
    Pacheco A, Mateos P, Medina J, Guisasola L, Garrillo F, Perez-Oteiza J (1987) Pulmonary tuberculosis and Schoenlein-Henoch purpura. Rev Clin Esp 180:515–517PubMedGoogle Scholar
  10. 10.
    Chan CHS, Chong YW, Sun AJM, Hoheisel GB (1990) Cutaneous vasculitis associated with tuberculosis and its treatment. Tubercle 71:297–300PubMedCrossRefGoogle Scholar
  11. 11.
    Visser AJ. Heyl T (1993) Skin tuberculosis as seen at Ga-Rankuwa hospital. Clin Exp Dermatol 18:507–515CrossRefGoogle Scholar
  12. 12.
    Sais G, Vidaller A, Jucgla A, Peyri J (1996) Tuberculous lymphadenitis presenting with cutaneous leukocytoclastic vasculitis. Clin Exp Dermatol 21:65–66PubMedCrossRefGoogle Scholar
  13. 13.
    Lee AY, Jang JH, Lee KH (1998) Two cases of leukocytoclastic vasculitis with tuberculosis. Clin Exp Dermatol 23:225–226PubMedCrossRefGoogle Scholar
  14. 14.
    Martinez V, Zeller V, Caumes E, Katlama C, Bricaire F (2000) Cutaneous vascultitis disclosing pulmonary tuberculosis. Ann Med Intern 151:664–666Google Scholar
  15. 15.
    Minguez P, Pintor E, Buron R, Diaz-Pollan B, Puche JJ, Pontes JC (2000) Pulmonary tuberculosis presenting with cutaneous leukocytoclastic vasculitis. Infection 28:55–57PubMedCrossRefGoogle Scholar
  16. 16.
    Johnson NMcl, McNicol MW, Burton Kee EJ, Mowbray JF (1981) Circulating immune complexes in tuberculosis. Thorax 36:610–617CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Hee Man Kim
    • 1
  • Yong-Beom Park
    • 1
  • Ho Young Maeng
    • 1
  • Soo-Kon Lee
    • 1
    Email author
  1. 1.Division of Rheumatology, Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea

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