Rheumatology International

, Volume 26, Issue 4, pp 309–313 | Cite as

Association between dynamic exercise therapy and IGF-1 and IGFBP-3 concentrations in the patients with rheumatoid arthritis

  • Meltem Alkan Melikoglu
  • Saliha Karatay
  • Kazim Senel
  • Fatih Akcay
Original Article

Abstract

We aimed to evaluate the relationship between short-term dynamic exercise therapy and insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in rheumatoid arthritis (RA) patients. Forty RA patients were assigned into dynamic or range of motion (ROM) exercise groups. Also control group carried out the same dynamic exercise protocol. Morning stiffness, pain (VAS), Health assessment questionnaire (HAQ) and Ritchie articular index (RAI) were evaluated and erythrocyte sedimentation rate, serum C-reactive protein, IGF-1 and IGFBP-3 levels of the participants were recorded. The assessments were determined before, at the 7th and 15th days of treatment. VAS and RAI scores were significantly improved by the dynamic exercises in RA patients. There were increases on IGF-1 in dynamic exercise group, although IGF-1 levels showed a decrease in ROM exercise and control groups. Also no significant changes were observed on IGFBP-3 in three groups. Our results suggest that short-term dynamic exercise therapy increases serum IGF-1 in RA patients. The manipulation of serum IGF-1 levels by dynamic exercise therapy may indicate the beneficial effects of dynamic exercise in RA patients.

Keywords

Rheumatoid arthritis IGF-1 IGFBP-3 Dynamic exercise 

References

  1. 1.
    Ekdahl C, Broman G (1992) Muscle strength, endurance, and aerobic capacity in rheumatoid arthritis: a comperative study with healthy subjects. Ann Rheum Dis 51:35–40PubMedGoogle Scholar
  2. 2.
    Swezey RL (1974) Essentials of physical management and rehabilitation in arthritis. Semin Arthritis Rheum 3:349–368CrossRefPubMedGoogle Scholar
  3. 3.
    Sutej PG, Hadler NM (1991) Current principles of rehabilitation for patients with rheumatoid arthritis. Clin Orthop 265:116–124PubMedGoogle Scholar
  4. 4.
    Semble EL (1995) Rheumatoid arthritis: new approaches for its evaluation and management. Arch Phys Med Rehabil 76:190–201CrossRefPubMedGoogle Scholar
  5. 5.
    Pool AJ, Axford JS (2001) The effects of exercise on the hormonal and immune systems in rheumatoid arthritis. Rheumatology (Oxford) 4:610–614Google Scholar
  6. 6.
    Lemmey A, Maddison P, Breslin A, Cassar P, Hasso N, McCann R, Whellams E, Holly J (2001) Association between insulin-like growth factor status and physical activity levels in rheumatoid arthritis. J Rheumatol 28:29–34PubMedGoogle Scholar
  7. 7.
    Froesch ER, Schmid C, Schwander J, Zapf J (1985) Actions of insulin-like growth factors. Annu Rev Physiol 47:443–467CrossRefPubMedGoogle Scholar
  8. 8.
    Hui W, Rowan AD, Cawston T (2001) Insulin-like growth factor-1 blocks collagen release and down regulates matrix metalloproteinase-1, −3, −8, and −13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α. Ann Rheum Dis 60:254–261CrossRefPubMedGoogle Scholar
  9. 9.
    Luyten FP, Hascall VC, Nissley SP, Morales TI, Reddi AH (1998) Insulin-like growth factors maintain steady state metabolism of proteoglycans in bovine articular cartilage explants. Arch Biochem Biophys 267:416–425CrossRefGoogle Scholar
  10. 10.
    Tyler JA (1989) IGF-1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines. Biochem J 260:543–549PubMedGoogle Scholar
  11. 11.
    Pehlman ET, Copeland KC (1990) Influence of physical activity on insulin-like growth factor-1 in healthy younger and older men. J Clin Endocrinol Metab 71:1468–1473PubMedGoogle Scholar
  12. 12.
    Eliakim A, Brasel JA, Mohan S, Barstow TJ, Berman N, Cooper DM (1996) Physical fitness, endurance training, and growth hormone-insulin-like growth factor-1 system in adolescent females. J Clin Endocrinol Metab 81:3986–3992CrossRefPubMedGoogle Scholar
  13. 13.
    Roelen CAM, de Vries WR, Koppeschaar HPF, Vervoorn C, Thijssen JHH, Blankenstein MA (1997) Plasma insulin-like growth factor-1 and high affinity growth hormone-binding protein levels increase after two weeks of strenuous physical training. Int J Sports Med 18:238–241PubMedGoogle Scholar
  14. 14.
    Vitiello MV, Wilkinson CW, Merriam GR, Moe KE, Prinz PN, Ralph DD, Colasurdo EA, Schwartz RS (1997) Successfull 6-month endurance training does not alter insulin-like growth factor-1 in healthy older men and women. J Gerontol 52:149–154Google Scholar
  15. 15.
    Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324PubMedGoogle Scholar
  16. 16.
    Hochberg MC, Chang RW, Dwosh I, Lindsey S, Pincus T, Wolfe F (1992) The American College of Rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis. Arthritis Rheum 35:498–502PubMedGoogle Scholar
  17. 17.
    Jackson A, Ross R (1992) Understanding exercise for health and fitness, 2nd edn. D. Armstrong Book Printing, Houston, pp32Google Scholar
  18. 18.
    Dixon S, Bird H (1981) Reproducibility along a 10 cm visual analogue scale. Ann Rheum Dis 40:87–89PubMedGoogle Scholar
  19. 19.
    Fries J, Spitz P, Kraines R, Holman H (1980) Measurements of patient outcome in arthritis. Arthritis Rheum 23:137–145PubMedGoogle Scholar
  20. 20.
    Ritchie DM, Boyle JA, Mclnnes JM, Jasani MK, Dalakos TG, Grieveson P et al (1968) Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med 37:393–406PubMedGoogle Scholar
  21. 21.
    Jivo L (1975) Rehabilitation and rheumatoid arthritis. Bull Rheum Dis 26:838–841PubMedGoogle Scholar
  22. 22.
    Semble EL, Loeser RF, Wise CM (1990) Therapeutic exercise for rheumatoid arthritis and osteoarthritis. Semin Arthritis Rheum 1904–1925Google Scholar
  23. 23.
    Van den Ende CHM, Vliet Vlieland TP, Munneke M, Hazes JM (1998) Dynamic exercise therapy in rheumatoid arthritis: a systematic review. Br J Rheumatol 37:677–687CrossRefPubMedGoogle Scholar
  24. 24.
    Van den Ende CHM, Breedveld FC, le Cessie S, Dijkmans BAC, de Mug AW, Hazes JMW (2000) Effect of intensive exercise on patients with active rheumatoid arthritis: a randomised clinical trial. Ann Rheum Dis 59:615–621CrossRefPubMedGoogle Scholar
  25. 25.
    Lange U, Teichmann J, Stracke H (2000) Correlation between TNF-alpha, IGF-1, biochemical markers of bone metabolism, markers of inflammation/disease activity, and clinical manifestations in ankylosing spondylitis. Eur J Med Res 5:507–511Google Scholar
  26. 26.
    Schmeling H, Seliger E, Horneff G (2003) Growth reconstitution in juvenile idiopathic arthritis treated with etanercept. Clin Exp Rheumatol 21:779–784PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Meltem Alkan Melikoglu
    • 1
  • Saliha Karatay
    • 1
  • Kazim Senel
    • 1
  • Fatih Akcay
    • 2
  1. 1.Department of Physical Medicine and Rehabilitation, Medical FacultyAtatürk Ü niversitesi Tıp FakültesiErzurumTurkey
  2. 2.Department of Biochemistry, Medical FacultyAtatürk Ü niversitesi Tıp FakültesiErzurumTurkey

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