Rheumatology International

, Volume 26, Issue 6, pp 567–572

Impact of pain severity and location on health-related quality of life

  • Dennis C. Ang
  • Kurt Kroenke
  • Colleen A. McHorney
Case Report

DOI: 10.1007/s00296-005-0025-z

Cite this article as:
Ang, D.C., Kroenke, K. & McHorney, C.A. Rheumatol Int (2006) 26: 567. doi:10.1007/s00296-005-0025-z


Despite evidence that persistent pain affects well-being, little is known about the relationship of the location of pain to psychological and functional well-being. To determine whether patients with musculoskeletal disorders (MSD) are more likely to be depressed and functionally disabled compared to patients with pain at other sites, we conducted a secondary data analysis of the Medical Outcome Study—an observational study of adult outpatients with chronic medical conditions. Of the 3,360 patients who completed the baseline assessment, 1,237 (36.8%) had MSD and 2,123 (63.2%) had no MSD. Among patients in the MSD group, 84.5% reported ≥mild pain as compared to 70% in the no MSD. In multivariate analyses, MSD patients were more likely than non-MSD patients to be depressed (β coefficient=−1.9, p=0.008) and functionally disabled (β coefficient=−4.4, p<0.0001). However, the impact of MSD was eliminated after controlling for pain severity. Regardless of the location of pain, pain severity appears to be an important correlate of functional status, both mental and physical.


Musculoskeletal disorders Chronic pain Depression Physical function Observational study 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Dennis C. Ang
    • 1
  • Kurt Kroenke
    • 2
  • Colleen A. McHorney
    • 2
    • 3
  1. 1.Division of RheumatologyIndiana University School of Medicine USA
  2. 2.Division of General Internal Medicine and GeriatricsRegenstrief Institute Inc., Indiana University School of MedicineIndianapolisUSA
  3. 3.HSR&D Program at the Roudebush VAMCIndianapolisUSA

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