Rheumatology International

, Volume 26, Issue 6, pp 556–560 | Cite as

General or personal diet: the individualized model for diet challenges in patients with rheumatoid arthritis

  • Saliha KaratayEmail author
  • Teoman Erdem
  • Ahmet Kiziltunc
  • Meltem Alkan Melikoglu
  • Kadir Yildirim
  • Ebru Cakir
  • Mahir Ugur
  • Akin Aktas
  • Kazim Senel
Original Article


This study was performed to evaluate the effect of individualized diet challenges consisting of allergen foods on disease activity in rheumatoid arthritis (RA) patients. Twenty patients with positive skin prick test (SPT) response for food extracts and 20 with negative SPT response were included. All patients were instructed to restrict the most common allergen foods during 12 days and then assigned into two groups according to SPT results. Food challenges were performed with all of the allergen foods in prick test positive group (PTPG) and with corn and rice in prick test negative group (PTNG) during 12 days. Allergen foods were then eliminated from PTPG patients’ diet, while corn and rice were removed in PTNG. Clinical evaluations were performed after fasting (baseline), at the end of the challenge phase and reelimination phase. Stiffness, pain, physician’s and patient’s global assessment of disease activity, health assessment questionnaire (HAQ), Ritchie’s index, serum amyloid A protein, erythrocyte sedimentation rate and C-reactive protein were determined. All of the disease variables, except HAQ, were increased with food challenges in PTPG. In PTNG, no significant change was observed in any of the variables except pain (P<0.05) and patient’s global assessment (P<0.05). Our results showed that the individualized dietary manipulations may effect the disease activity for selected RA patients.


Rheumatoid arthritis Food allergy Food challenges Disease activity Skin prick test 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Saliha Karatay
    • 1
    Email author
  • Teoman Erdem
    • 2
  • Ahmet Kiziltunc
    • 3
  • Meltem Alkan Melikoglu
    • 1
  • Kadir Yildirim
    • 1
  • Ebru Cakir
    • 2
  • Mahir Ugur
    • 1
  • Akin Aktas
    • 2
  • Kazim Senel
    • 1
  1. 1.Departments of Physical Medicine and RehabilitationAtatürk Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim DalıErzurumTurkey
  2. 2.Department of Dermatology, Medical FacultyAtatürk UniversityErzurumTurkey
  3. 3.Department of Biochemistry, Medical FacultyAtatürk UniversityErzurumTurkey

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