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Auditory event-related brain potentials in fibromyalgia syndrome



The aim of this study was to investigate cognitive functions using auditory event-related brain potentials (ERP) in fibromyalgia syndrome (FMS).


The P300 component of ERP was studied in 36 female FMS patients and 22 control subjects. The short form 36 (SF-36) medical outcome study was used to determine quality of life. Number of tender points and disease duration were noted. Cognitive functions were evaluated with P300.


The symptoms were discrepant in FMS (P<0.001). The scores of the eight SF-36 subgroups in FMS patients were significantly lower than in the control group (P<0.001). Fibromyalgia syndrome patients had prolonged latency and reduced amplitude of P300 (P<0.001). No correlation was found between the subgroups of SF-36, tender point count, disease duration, and P300.


The results of our study reveal that FMS affects quality of life and dysfunction in cognitive abilities can be determined by brain event-related potentials.

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Correspondence to Ece Alanoğlu.

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Alanoğlu, E., Ulaş, U.H., Özdağ, F. et al. Auditory event-related brain potentials in fibromyalgia syndrome. Rheumatol Int 25, 345–349 (2005).

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  • Cognitive dysfunction
  • Brain event-related potentials
  • Fibromyalgia
  • P300
  • Short form 36