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Rheumatology International

, Volume 25, Issue 3, pp 205–210 | Cite as

Radon therapy for the treatment of rheumatic diseases—review and meta-analysis of controlled clinical trials

  • Albrecht FalkenbachEmail author
  • J. Kovacs
  • A. Franke
  • K. Jörgens
  • K. Ammer
Original Article

Abstract

Objective

The aim of this study was to analyze the effect of radon therapy on pain in rheumatic diseases.

Methods

MEDLINE and MedKur databases were searched for the terms radon plus therapy, rheum, arthritis, and osteo. Radon therapy centers and experts in the field were contacted, proceedings hand-searched, and bibliographies checked for references of potential importance. Included were all prospective randomized controlled clinical trials that compared clinical effects of radon therapy with other interventions in patients with rheumatic diseases and studied pain intensity. Information concerning patients, interventions, results, and methodology were extracted in a standardized manner by all authors independently and summarized descriptively. Reports on pain reduction were pooled for meta-analysis.

Results

Five clinical trials with a total of 338 patients and comparing the effect on pain of radon baths (three trials) or radon speleotherapy (two trials) with control intervention in degenerative spinal disease (two trials), rheumatoid arthritis (one trial) and ankylosing spondylitis (two trials) met the inclusion criteria. In meta-analysis, the pooled data showed no difference immediately after treatment (P=0.13) but significantly better pain reduction in the radon group than the control group at 3 months (P=0.02) and 6 months (P=0.002) after treatment.

Conclusions

The existing trials suggest a positive effect of radon therapy on pain in rheumatic diseases. With respect to the potential clinical effect and given the increasing public interest in radon therapy, there is an urgent need for further randomized controlled clinical investigations with long-term follow-up.

Keywords

Ankylosing spondylitis Radon Rheumatoid arthritis Spa Spinal disease 

References

  1. 1.
    Deetjen P (1992) Radon-Balneotherapie—neue Aspekte. Phys Rehab Kur Med 2:100–103Google Scholar
  2. 2.
    Pershagen G, Akerblom G, Axelson O et al (1994) Residential radon exposure and lung cancer in Sweden. N Engl J Med 330:159–164Google Scholar
  3. 3.
    Steindorf K, Lubin J, Wichmann HE, Becher H (1995) Lung cancer deaths attributable to indoor radon exposure in West Germany. Int J Epidemiol 24:485–492PubMedGoogle Scholar
  4. 4.
    Bogoljubow VM, Davydowa OB, Andrejew (1990) Radon-Luftbäder in der UdSSR: Forschung und Einsatz. Z Phys Med Baln Med Klim 19 [Sonderheft 2]:90–98Google Scholar
  5. 5.
    Pratzel HG, Schnizer W (1992) Handbuch der medizinischen Bäder: Radon-Bäder. Haug, Heidelberg, pp 125–129Google Scholar
  6. 6.
    Yamaoka K, Komoto Y (1996) Experimental study of alleviation of hypertension, diabetes and pain by radon inhalation. Physiol Chem Phys Med NMR 28:1–5PubMedGoogle Scholar
  7. 7.
    Yonehara H, Ma J, Ikebuchi M, Aoyama T (1999) Changes in superoxide dismutase (SOD) activity in organs of rat induced by radon exposure. In: Inaba J, Yonehara H, Doi M (eds) Indoor radon exposure and its health consequences. Kodansha, Tokyo, pp 123–129Google Scholar
  8. 8.
    Yamaoka K, Mifune T, Mitsunobu F, Kojima S, Mori S, Shibuya K, Tanizaki Y, Sugita K (2001) Basic studies on radon effects and thermal effects on humans in radon therapy. Physiol Chem Phys Med NMR 33:133–138PubMedGoogle Scholar
  9. 9.
    Pfaller W (1979) Subzelluläre Veränderungen der Nebennierenrinde nach Inhalation von 222Rn. Z Angew Bäder- u Klimaheilk 26:384–390Google Scholar
  10. 10.
    Reinisch N, Mur E, Herold M, Dunzendorfer S, Kähler CM, Falkenbach A, Wiedermann CJ (1999) Decrease of respiratory burst in neutrophils of patients with ankylosing spondylitis by combined radon-hyperthermia treatment. Clin Exp Rheumatol 17:335–338PubMedGoogle Scholar
  11. 11.
    Pratzel HG, Legler B, Heisig S, Klein G (1999) Schmerzstillender Langzeiteffekt durch Radonbäder bei nicht entzündlichen rheumatischen Erkrankungen. In: Deetjen P, Falkenbach A (eds) Radon und Gesundheit. Lang, Frankfurt, pp 163–182Google Scholar
  12. 12.
    Hofmann W, Lettner H, Winkler R, Foisner W (1999) Perkutaner Radon-Transfer und Strahlenexposition durch Radonzerfallsprodukte beim Radon-Thermalwasserbad. In: Deetjen P, Falkenbach A (eds) Radon und Gesundheit. Lang, Frankfurt, pp 83–91Google Scholar
  13. 13.
    Falkenbach A, Just G, Soto J (2000) Radon progeny activity in sweat following radon exposure in a warm and humid environment. Radiat Environm Biophys 39:137–139CrossRefGoogle Scholar
  14. 14.
    Falkenbach A, Kleinschmidt J, Soto J, Just G (2002) Radon progeny activity on skin and hair after speleotherapeutic radon exposure. J Environ Radioactivity 62:217–223CrossRefGoogle Scholar
  15. 15.
    Jadad M, Moore M, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ et al (1996) Assessing the quality of reports of randomised clinical trials: is blinding necessary? Control Clin Trials 17:1–12PubMedGoogle Scholar
  16. 16.
    Pratzel HG, Legler B, Aurand K, Baumann K, Franke T (1993) Wirksamkeitsnachweis von Radonbädern im Rahmen einer kurortmedizinischen Behandlung des zervikalen Schmerzsyndroms. Phys Rehab Kur Med 3:76–82Google Scholar
  17. 17.
    Clarke M, Oxman AD (2000) Analysing and presenting results. Handbook 4.1, section 8, in the Review Manager (RevMan) computer program, version 4.1. Cochrane, OxfordGoogle Scholar
  18. 18.
    Lind-Albrecht G (1994) Einfluss der Radonstollentherapie auf Schmerzen und Verlauf bei Spondylitis ankylosans. Thesis, Johannes Gutenberg University, MainzGoogle Scholar
  19. 19.
    Fischer AA (1986) Pressure threshold meter: its use for quantification of tender spots. Arch Phys Med Rehabil 67:836–838PubMedGoogle Scholar
  20. 20.
    Franke A, Reiner L, Pratzel HG, Franke T, Resch KL (2000) Long-term efficacy of radon spa therapy in rheumatoid arthritis—a randomised, sham-controlled study and follow-up. Rheumatology (Oxford) 39:894–902Google Scholar
  21. 21.
    van Tubergen A, Landewé R, van der Heijde D, Hidding A, Wolter N, Asscher M, Falkenbach A, Genth E, Goei Thé H, van der Linden S (2001) Combined spa-exercise therapy is effective in ankylosing spondylitis patients: a randomised controlled trial. Arthritis Rheum 45:430–438CrossRefPubMedGoogle Scholar
  22. 22.
    Zielke VA, Just L, Schubert M, Tautenhahn B (1973) Objective evaluation of complex balneotherapy based on the use of radon in ankylosing spondylitis and rheumatoid arthritis [German]. Z Physiother 25:113–117PubMedGoogle Scholar
  23. 23.
    Aryppaeva TT (1974) Dynamics of the activity of lysosomal enzymes and proteoglycan-like compounds in patients with primary deforming osteoarthrosis under the effect of radon baths with radon concentration: 100 (36.4 nKi/l) and 3000 (109.2 nKi/l) Mache units [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:509–512Google Scholar
  24. 24.
    Tsarfis PG, Kostrova VD, Gerasimenko VN, Fiveiskaia AA (1974) Effect of radon baths with radon concentration of 100 Mache units (36.4 nKi/l) on the patients with deforming osteoarthritis with myocardial lesion [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:506–509Google Scholar
  25. 25.
    Tsarfis PG, Gerasimenko VN, Fiveiskaia AA, Proskurova GI, Vetrova LP (1975) Use of radon baths of different concentrations in osteoarthritis deformans [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:241–219Google Scholar
  26. 26.
    Asalkhanov IUA (1976) Comparative effectiveness of the use of radon baths at concentrations of 40 and 200 nCi/l in the treatment of ankylosing spondylitis. Vopr Kurortol Fizioter Lech Fiz Kult:39–41Google Scholar
  27. 27.
    Fiveiskaia AA (1976) Effectiveness of treatment of rheumatoid arthritis with radon baths of different concentrations [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:35–39Google Scholar
  28. 28.
    Gerasimenko VN (1976) Treatment of osteoarthritis deformans with radon baths of high concentration [200 and 400 nCi/l]. Vopr Kurortol Fizioter Lech Fiz Kult:28–31Google Scholar
  29. 29.
    Pshetakovskii IL (1976) Mechanism of the action and the effectiveness of radon treatment of rheumatoid arthritis of varied activity [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:31–35Google Scholar
  30. 30.
    Tsarfis PG (1976) Therapeutic effect of radon baths of different concentrations in inflammatory and dystrophic diseases [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:1–7Google Scholar
  31. 31.
    Steiner FJF, Valkenburg HA, van de Stadt RJ, Stoyanova-Drenska M, Zant J (1979) Spa therapy in patients with rheumatoid arthritis [Dutch]. Ned T Geneesk 16:661–664Google Scholar
  32. 32.
    Tondii LD, Vasilieva-Linetskaia LIa, Shtern MR (1979) Effect of Ichthyol electrophoresis with sinusoidal modulated currents combined with radon baths on the clinical biochemical indices in osteoarthrosis deformans [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:53–56Google Scholar
  33. 33.
    Sorokina EI, Davydova OB, Shubina AV, Riazantsev KM (1981) High-frequency electromagnetic fields and radon baths in the treatment of rheumatism [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:56–60Google Scholar
  34. 34.
    Mikunis RI, Dubovoi AF, Adamenko DL, Boiko IA (1985) Use of dry-air radon baths at the sanatorium stage of rehabilitation of patients with rheumatoid arthritis. Vopr Kurortol Fizioter Lech Fiz Kult:61–63Google Scholar
  35. 35.
    Trigorieva VD, Lomsadze VS (1985) Use of natural, weak hydrogen sulfide waters artificially enriched with radon in patients with osteoarthrosis deformans [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:43–46Google Scholar
  36. 36.
    Tsarfis PG, Kopieva TN, Abdusliamova LI, Makarova OV (1987) Effect of radon baths and their combination with decimeter-wave therapy on the joint syndrome in rheumatoid arthritis. Vopr Kurortol Fizioter Lech Fiz Kult:25–29Google Scholar
  37. 37.
    Galliamov AG, Valeev RG (1990) Radon therapy and the use of acupuncture reflexotherapy in patients with cervical and lumbar osteochondrosis [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:50Google Scholar
  38. 38.
    Shliapak EA, Gabidova NT, Evseeva SN, Apanasevich ZK, Shvedunova LN (1992) A low-frequency alternating magnetic field and its combination with radon baths in juvenile rheumatoid arthritis [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult 4:13–17PubMedGoogle Scholar
  39. 39.
    Veinpalu EIU, Trink RF, Veinpalu LE, Pyder KhA (1992) The therapeutic action of low-water bulk of therapeutic sea mud. Vopr Kurortol Fizioter Lech Fiz Kult:54–57Google Scholar
  40. 40.
    Bernatzky G, Graf AH, Saria A, Hofmann W, Lettner H, Adam H, Leiner G (1994) Schmerzhemmende Wirkung einer Kurbehandlung bei Patienten mit Spondylitis ankylopoetica. Österr Z Phys Med 4:85–94Google Scholar
  41. 41.
    Dicheva MA, Khyshiktuev BS, Anikina LV, Popov VM (1998) Changes in the mineral metabolic indices of osteoarthrosis patients with the use of radon therapy and mud therapy. Vopr Kurortol Fizioter Lech Fiz Kult:37–38Google Scholar
  42. 42.
    Falkenbach A, Wolter NJGB, Herold M (1999) Klinische Studien zur Wirksamkeit der Radonthermalstollen-Behandlung bei Morbus Bechterew. In: Deetjen P, Falkenbach A (eds) Radon und Gesundheit. Lang, Frankfurt, pp 111–129Google Scholar
  43. 43.
    Skorepa P, Klein G, Pratzel HG (1999) Wirkungsverstärkender Effekt von Radonbädern durch CO2. In: Deetjen P, Falkenbach A (eds) Radon und Gesundheit. Lang, Frankfurt, pp 103–109Google Scholar
  44. 44.
    Hunt DL, McKibbon K (1997) Locating and appraising systematic reviews. Ann Intern Med 126:532–538PubMedGoogle Scholar
  45. 45.
    Meade MO, Richardson WS (1997) Selecting and appraising studies for a systematic review. Ann Intern Med 127:531–537PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Albrecht Falkenbach
    • 1
    • 2
    Email author
  • J. Kovacs
    • 1
  • A. Franke
    • 3
  • K. Jörgens
    • 4
  • K. Ammer
    • 5
  1. 1.Gasteiner Heilstollen HospitalBad Gastein-BöcksteinAustria
  2. 2.Gastein Research InstituteBad GasteinAustria
  3. 3.Coordination Center for Clinical TrialsUniversity of LeipzigLeipzigGermany
  4. 4.Rosentritt KlinikBad RappenauGermany
  5. 5.Ludwig Boltzmann Research Institute for Physical DiagnosticsViennaAustria

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