Rheumatology International

, Volume 23, Issue 5, pp 211–215

Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes


DOI: 10.1007/s00296-003-0355-7

Cite this article as:
Endresen, G.K.M. Rheumatol Int (2003) 23: 211. doi:10.1007/s00296-003-0355-7


Chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) are characterised by a lack of consistent laboratory and clinical abnormalities. Although they are distinguishable as separate syndromes based on established criteria, a great number of patients are diagnosed with both. In studies using polymerase chain reaction methods, mycoplasma blood infection has been detected in about 50% of patients with CFS and/or FMS, including patients with Gulf War illnesses and symptoms that overlap with one or both syndromes. Such infection is detected in only about 10% of healthy individuals, significantly less than in patients. Most patients with CFS/FMS who have mycoplasma infection appear to recover and reach their pre-illness state after long-term antibiotic therapy with doxycycline, and the infection can not be detected after recovery. By means of causation and therapy, mycoplasma blood infection may permit a further subclassification of CFS and FMS. It is not clear whether mycoplasmas are associated with CFS/FMS as causal agents, cofactors, or opportunistic infections in patients with immune disturbances. Whether mycoplasma infection can be detected in about 50% of all patient populations with CFS and/or FMS is yet to be determined.


Chronic fatigue syndrome Fibromyalgia Mycoplasma infection Persian Gulf syndrome Polymerase chain reaction 

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Department of RheumatologyThe National Hospital, University of OsloOsloNorway

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