Rheumatology International

, Volume 24, Issue 3, pp 157–163

Glutathione S-transferase M1, T1, and P1 gene polymorphisms and carotid atherosclerosis in Korean patients with rheumatoid arthritis

  • Jae-Hong Park
  • Ahmed El-Sohemy
  • Marilyn C. Cornelis
  • Hyun-Ah Kim
  • Shin-Yoon Kim
  • Sang-Cheol Bae
Original Article

DOI: 10.1007/s00296-003-0347-7

Cite this article as:
Park, JH., El-Sohemy, A., Cornelis, M.C. et al. Rheumatol Int (2004) 24: 157. doi:10.1007/s00296-003-0347-7

Abstract

We assessed the contribution of genetic polymorphisms of glutathione S-transferase M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1, Ile105Val) to carotid atherosclerosis in 40 postmenopausal rheumatoid arthritic (RA) women without histories of smoking. We measured mean intima-media thickness (IMT) and plaque of the common carotid arteries by ultrasonography and evaluated relationships among the known risk factors for atherosclerosis, genetic polymorphisms, RA outcomes, and markers of inflammation. Subjects with the GSTT1–0 genotype had greater IMT (P<0.05). On univariate analysis, carotid IMT was positively associated with age, systolic BP, antihypertensive drug use, and the GSTT1–0 genotype (P<0.05). When compared to subjects with a double-positive GSTM1/T1 genotype, IMT in those with concurrent lack of the GSTM1 and GSTT1 genes was significantly increased (P=0.008). This study suggests that the GSTT1–0 genotype might have an interaction with carotid atherosclerosis related to RA in Korean postmenopausal RA women without histories of smoking.

Keywords

Atherosclerosis Genetic polymorphism Glutathione S-transferase Rheumatoid arthritis 

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Jae-Hong Park
    • 1
  • Ahmed El-Sohemy
    • 2
  • Marilyn C. Cornelis
    • 2
  • Hyun-Ah Kim
    • 3
  • Shin-Yoon Kim
    • 4
  • Sang-Cheol Bae
    • 1
  1. 1.Division of Rheumatology, Department of Internal MedicineHanyang University College of Medicine and the Hospital for Rheumatic DiseasesSeoul 133–792Korea
  2. 2.Department of Nutritional SciencesUniversity of TorontoTorontoCanada
  3. 3.Hallym UniversityKangdong Sacred Heart HospitalSeoulKorea
  4. 4.Department of Orthopedic Surgery, College of MedicineKyungpook National UniversityDaeguKorea

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