RS3PE syndrome: a clinical and immunogenetical study
- 177 Downloads
This study analyses the clinical, radiological, evolutive, and immunogenetical characteristics of a series of patients diagnosed with remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. Reviewed were the clinical charts and human leukocyte antigen (HLA) profiles of all patients treated at a single teaching hospital fulfilling the features of this syndrome according to the definition of McCarty. Twelve cases were detected in ten men and two women aged from 62 to 85 years. Rheumatoid factor was negative in all cases, and antinuclear antibodies (ANA) were positive in two. All patients achieved complete resolution of their condition within 1 year with glucocorticoid (GC) use. Two relapsed after remission but responded again to low doses of GC. Four patients showed clinical and electrodiagnostic studies consistent with carpal tunnel syndrome. No specific HLA association could be found in this report. To date, none of these patients has developed definite rheumatic diseases, infections, or malignant diseases. Although the real nature of the syndrome is still a matter of debate, at least in our context, RS3PE remains a definite condition with an excellent prognosis.
KeywordsRS3PE Human leukocyte antigens Pitting edema Polyarthritis
- 3.Sibilia J, Friess S, Schaeverbeke T, Maloisel F, Bertin P, Goichot B et al (1999) Remitting seronegative symmetrical synovitis with pitting edema (RS3PE): a form of paraneoplastic polyarthritis? J Rheumatol 26:115–120Google Scholar
- 7.Schaeverbeke T, Fatout E, Marce S, Vernhes JP, Halle O, Antoine JP et al (1995) Remitting seronegative symmetrical synovitis with pitting edema: disease or syndrome? Ann Rheum Dis 54:681–684Google Scholar
- 10.Toussirot E, Berthier S, Wendling D, Tiberghien P (1998) Lack of association between HLA DRB1* alleles and RS3PE syndrome. Ann Rheum Dis 57:442Google Scholar
- 11.Cedoz JP, Wendlin D, Viel JF (1995) The B7 cross-reactive group and spondyloarthropathies: an epidemiological approach. J Rheumatol 22:1184–1190Google Scholar