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Rheumatology International

, Volume 21, Issue 4, pp 149–152 | Cite as

Correlation of serum levels of soluble intercellular adhesion molecule-1 with disease activity in systemic lupus erythematosus

  • Refik Sari
  • Seyithan Taysi
  • Fuat Erdem
  • Ömer Yilmaz
  • Said Keleş
  • Ahmet Kiziltunç
  • Ali Odabaş
  • Ramazan Çetinkaya
Original Article

Abstract.

Intercellular adhesion molecule-1 (ICAM-1) is a membrane-bound molecule primarily involved in cell-cell adhesive interactions of the immune system. It is a cytokine-induced glycoprotein involved in the recruitment of cells into tissues undergoing inflammatory responses. The levels of soluble ICAM-1 were measured in sera of patients with systemic lupus erythematosus (SLE) using sandwich enzyme-linked immunoassay. Serum levels (mean±SD) of soluble ICAM-1 (sICAM-1) were significantly higher in 24 patients with SLE than in 20 controls (372±42 ng/dL vs 231±29 ng/dL, P<0.001). A statistically significant positive correlation was observed between sICAM-1 levels and SLE disease activity index (SLEDAI) score in SLE patients, and no correlation was found between sICAM-1 and CRP, SLEDAI and CRP, or SLEDAI and ESR in patient groups (P>0.05). These findings suggest that sICAM-1 measurement may serve as an additional serologic marker of disease activity in patients with SLE.

Cell adhesion Soluble ICAM-1 SLE 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Refik Sari
    • 1
  • Seyithan Taysi
    • 2
  • Fuat Erdem
    • 1
  • Ömer Yilmaz
    • 1
  • Said Keleş
    • 2
  • Ahmet Kiziltunç
    • 2
  • Ali Odabaş
    • 1
  • Ramazan Çetinkaya
    • 1
  1. 1.Department of Internal Medicine, Faculty of Medicine, Atatürk University, Erzurum, TurkeyTurkey
  2. 2.Department of Biochemistry, Faculty of Medicine, Atatürk University, Erzurum, TurkeyTurkey

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