Advertisement

Rheumatology International

, Volume 21, Issue 3, pp 122–126 | Cite as

Elevation of soluble interleukin-2 receptor levels in the bronchoalveolar lavage from patients with systemic sclerosis

  • José Martinez
  • Cinthya Nishimura
  • Sandra Guatura
  • Emilia Sato
  • Talmadge E. King
Original Article

Abstract.

This study was designed to investigate the levels of IL-2 and its soluble receptor (sIL-2R) in bronchoalveolar lavage fluid (BALF) from patients with systemic sclerosis (SSc). We studied 18 patients with SSc and 10 healthy volunteers. Based on high-resolution computed tomography lung scans the patients were divided into two groups, those with (SSc-ILD group, n=10) and those without (SSc group, n=8) evidence of interstitial lung disease (ILD). Both groups showed significantly higher total cell and neutrophil counts in the BALF than controls. The SSc group also showed significantly higher levels of lymphocytes than controls. IL-2 was not detectable in BALF. The patients showed significantly higher levels of sIL-2R than controls (77.8% vs 20%, P=0.005). The median sIL-2R levels detected did not differ between the two patient groups (SSc-ILD 270 pg/ml, SSc 232 pg/ml). This study suggests that SSc patients with or without ILD have elevated levels of sIL-2R in BALF and that in some of these patients this finding could be explained by subclinical pulmonary inflammation.

Soluble interleukin-2 receptor Bronchoalveolar lavage Systemic sclerosis Interstitial lung disease 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • José Martinez
    • 1
  • Cinthya Nishimura
    • 1
  • Sandra Guatura
    • 1
  • Emilia Sato
    • 1
  • Talmadge E. King
    • 2
  1. 1.Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
  2. 2.Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA

Personalised recommendations