Multifaceted activities of DNA polymerase η: beyond translesion DNA synthesis
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DNA polymerases are evolved to extend the 3′-OH of a growing primer annealed to a template DNA substrate. Since replicative DNA polymerases have a limited role while replicating structurally distorted template, translesion DNA polymerases mostly from Y-family come to the rescue of stalled replication fork and maintain genome stability. DNA polymerase eta is one such specialized enzyme whose function is directly associated with casual development of certain skin cancers and chemo-resistance. More than 20 years of extensive studies are available to support TLS activities of Polη in bypassing various DNA lesions, in addition, limited but crucial growing evidence also exist to suggest Polη possessing TLS-independent cellular functions. In this review, we have mostly focused on non-TLS activities of Polη from different organisms including our recent findings from pathogenic yeast Candida albicans.
KeywordsHomologous recombination Chromosomal fragile sites Antibody diversification Transcription Germ tube Candida Amphotericin B
We thank our laboratory colleagues for helpful discussions and critical comments. Special mention to Mr. Sitendra Panda for his technical assistance during the course of the study. Work in NA’s laboratory is supported by Institutional core support, DBT (BT/PR15470/MED/29/997/2015), and SERB (EMR-2016-000640). We apologize that due to space limitation, not all of the work related to this field could be discussed or cited.
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