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Current Genetics

, Volume 64, Issue 4, pp 807–810 | Cite as

Stress response factors drive regrowth of quiescent cells

Review

Abstract

Quiescent cells exploit an array of transcription factors to activate stress response machinery and maintain survival under nutrient-limited conditions. Our recent findings reveal that these transcription factors also play an important role in the exit of quiescence and regrowth. By studying Saccharomyces cerevisiae under a continuous, nutrient-limited condition, we found that Msn2 and Msn4 function as master regulators of glycolytic genes in the quiescent-like phase. They control the timing of transition from quiescence to growth by regulating the accumulation rate of acetyl-CoA, a key metabolite that is downstream of glycolysis and drives growth. These findings suggest a model that Msn2/4 not only protect the cells from starvation but also facilitate their regrowth from quiescence. Thus, understanding the functions of stress response transcription factors in metabolic regulation will provide deeper insight into how quiescent cells manage the capacity of regrowth.

Keywords

Msn2 Msn4 Glycolysis Acetyl-CoA Quiescence exit Regrowth 

Notes

Acknowledgements

Supported by NIH Grant 5P50GM107632-06 to H.J. and J.D.B and R01HG006282 to H.J.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ImmunologyUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Department of BiostatisticsJohns Hopkins University School of Public HealthBaltimoreUSA
  3. 3.Institute for Systems Genetics, Department of Biochemistry and Molecular PharmacologyNYU Langone HealthNew York CityUSA

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