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Current Genetics

, Volume 64, Issue 1, pp 141–146 | Cite as

MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus

  • Özlem Sarikaya Bayram
  • Jean Paul Latgé
  • Özgür Bayram
Review

Abstract

Aspergillus fumigatus is an opportunistic human pathogen that causes various complications in patients with a weakened immune system functions. Asexual spores of A. fumigatus are responsible for initiation of aspergillosis. Long-term viability and proper germination of dormant conidia depend on trehalose accumulation, which protect the spores against thermal and oxidative stress. A putative Myb transcription factor, MybA has been recently found to be responsible for a variety of physiological and molecular roles ranging from conidiation, spore viability, trehalose accumulation, cell wall integrity and protection against reactive oxygen species. In this perspective review, we discuss the recent findings of MybA and its overlapping functions with the other regulators of conidia viability and trehalose accumulation. Therefore, the aim of this perspective is to raise interesting and stimulating questions on the molecular functions of MybA in conidiation and trehalose biogenesis and to question its genetic and physical interactions with the other regulators of conidial viability.

Keywords

MybA Spore viability VelB-VosA Cell wall Aspergillus fumigatus AtfA WetA 

Notes

Acknowledgements

This publication has emanated from research supported by a research Grant from Science Foundation Ireland (SFI) under Grant Number 13/CDA/2142 to Ozgur Bayram. Ozlem Sarikaya Bayram is supported by the Irish Research Council (IRC) Postdoctoral Fellowship (GOIPD/2014/178).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Biology DepartmentMaynooth UniversityMaynooth, Co. KildareIreland
  2. 2.Unité des AspergillusInstitut PasteurParisFrance

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