Current Genetics

, Volume 64, Issue 1, pp 17–23 | Cite as

Spo0M: structure and function beyond regulation of sporulation

  • Luz Adriana Vega-Cabrera
  • Christopher D. Wood
  • Liliana Pardo-López


In this mini-review, we present a perspective on the recent findings relating Spo0M structure and function that will stimulate and guide further studies in the characterization of this interesting protein. Cell division and sporulation constitute two of the best studied processes in the model organism Bacillus subtilis; however, there are many missing pieces in the giant regulatory puzzle that governs the independent and shared networks between them. Spo0M is a little studied protein that has been related to both, cell division and sporulation, but its biochemical function and its direct interactions have not been yet defined. Structural analysis of Spo0M revealed the presence of an arrestin-like domain and an FP domain (a dimerization domain present in proteasome elements), motifs more commonly found in eukaryotic proteins. The aim of this perspective is to present open questions regarding the functional and structural features of Spo0M that make this protein a good candidate for the ancestor of arrestins in bacteria and an important element in developmental and differentiation processes of Bacillus subtilis.


Spo0M Bacillus subtilis Sporulation Cell division Arrestins Stress response 



We thank Dr. Enrique Merino and Dr. Rosa María Gutiérrez-Ríos for enriching discussions regarding the genetic context, homology, and physiology of Spo0M. We thank Shirley Ainsworth for bibliographical assistance. This work was supported partially by CONACyT 176381 and DGAPA IN 204016. Luz Adriana Vega-Cabrera was supported by a CONACyT and DGAPA scholarship.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Instituto de BiotecnologíaUniversidad Nacional Autónoma de MéxicoCuernavacaMexico
  2. 2.Laboratorio Nacional de Microscopía AvanzadaUniversidad Nacional Autónoma de MéxicoCuernavacaMexico

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