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Current Genetics

, Volume 59, Issue 3, pp 73–90 | Cite as

Candida guilliermondii: biotechnological applications, perspectives for biological control, emerging clinical importance and recent advances in genetics

  • Nicolas PaponEmail author
  • Vincenzo Savini
  • Arnaud Lanoue
  • Andrew J. Simkin
  • Joël Crèche
  • Nathalie Giglioli-Guivarc’h
  • Marc Clastre
  • Vincent Courdavault
  • Andriy A. SibirnyEmail author
Review

Abstract

Candida guilliermondii (teleomorph Meyerozyma guilliermondii) is an ascomycetous species belonging to the Saccharomycotina CTG clade which has been studied over the last 40 years due to its biotechnological interest, biological control potential and clinical importance. Such a wide range of applications in various areas of fundamental and applied scientific research has progressively made C. guilliermondii an attractive model for exploring the potential of yeast metabolic engineering as well as for elucidating new molecular events supporting pathogenicity and antifungal resistance. All these research fields now take advantage of the establishment of a useful molecular toolbox specifically dedicated to C. guilliermondii genetics including the construction of recipient strains, the development of selectable markers and reporter genes and optimization of transformation protocols. This area of study is further supported by the availability of the complete genome sequence of the reference strain ATCC 6260 and the creation of numerous databases dedicated to gene ontology annotation (metabolic pathways, virulence, and morphogenesis). These genetic tools and genomic resources represent essential prerequisites for further successful development of C. guilliermondii research in medical mycology and in biological control by facilitating the identification of the multiple factors that contribute to its pathogenic potential. These genetic and genomic advances should also expedite future practical uses of C. guilliermondii strains of biotechnological interest by opening a window into a better understanding of the biosynthetic pathways of valuable metabolites.

Keywords

Candida guilliermondii Biotechnology Biological control Pathogenicity Antifungal resistance Molecular tools 

Notes

Acknowledgments

We thank Christophe d’Enfert (Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, Paris, France) and Alexander D. Johnson (University of California, Department of Microbiology & Immunology, San Francisco, USA) for providing gLUC59 and S. thermophiles LacZ, respectively. We acknowledge Françoise Dromer and Marie Desnos-Ollivier (National Reference Center for Mycoses and Antifungals, Institut Pasteur, Paris, France) for providing various C. guilliermondii isolates. We acknowledge the Broad Institute Fungal Genome Initiative for making the complete genome sequence of C. guilliermondii available.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Nicolas Papon
    • 1
    Email author
  • Vincenzo Savini
    • 2
  • Arnaud Lanoue
    • 1
  • Andrew J. Simkin
    • 3
  • Joël Crèche
    • 1
  • Nathalie Giglioli-Guivarc’h
    • 4
  • Marc Clastre
    • 1
  • Vincent Courdavault
    • 4
  • Andriy A. Sibirny
    • 5
    • 6
    Email author
  1. 1.EA2106, Biomolécules et Biotechnologies Végétales, Faculté de PharmacieUniversité François-Rabelais de ToursToursFrance
  2. 2.Microbiology and VirologySpirito Santo HospitalPescara (PE)Italy
  3. 3.School of Biological SciencesUniversity of EssexColchesterUK
  4. 4.EA2106, Biomolécules et Biotechnologies Végétales, Faculté des Sciences et TechniquesUniversité François-Rabelais de ToursToursFrance
  5. 5.Institute of Cell BiologyNAS of UkraineLvivUkraine
  6. 6.Department of Biotechnology and MicrobiologyUniversity of RzeszowRzeszowPoland

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